Fas Ligand (TNF Superfamily, Member 6) (FASL) antibody

Details for Product No. ABIN263613
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Antigen
Synonyms ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, Fas-L, Faslg, Tnfsf6, gld, Fasl, Apt1Lg1, fasl, FASLG, FAS, TNFRSF6, zgc:162027
Reactivity
Human
(206), (127), (57), (18), (6), (3), (3), (1), (1)
Host
Hamster
(116), (81), (59), (24), (5), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(31), (13), (13), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Functional Studies (Func), Flow Cytometry (FACS)
(157), (116), (81), (56), (40), (37), (22), (21), (18), (13), (10), (6), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1)
Pubmed 6 references available
Catalog no. ABIN263613
Quantity 0.1 mg
Price
753.50 $   Plus shipping costs $45.00
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Immunogen Recombinant human Fas ligand. Hybridization of P3U1 myeloma Hamster lymphocytes.
Clone 4A5
Isotype IgG
Characteristics Synonyms: FASLG, APT1LG1, FASL, TNFSF6, CD95L protein, APTL, Tumor necrosis factor ligandsuperfamily member 6, Fas antigen ligand, Apoptosis antigen ligand
Alternative Name CD178 / Fas Ligand
Background Apoptosis or programmed-cell death is a physiological process essential for the normaldevelopment and maintenance or homeostasis in many organisms. This cellular suicidecan be triggered by the interaction of two cell-surface molecules, the Fas antigen (CD95)and its ligand, the Fas ligand or FasL. The FasL is a type II membrane protein of M, 40kDaand is a member of the tumor necrosis factor (TNF) family. It is expressed by activated Tcells. A 26kDa soluble form of human FasL (sFasL) exists and has been detected in thesupernatant of human peripheral NK cells and lymphocytes upon activation.
UniProt P48023
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry: Recommended: 10g/ml as a final concentration. ELISA. Neutralization of soluble Fas ligand cytotoxic-activity. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Restore with 100 µL of distilled water.
Buffer Lyophilized from PBS containing 1% sucrose
Preservative Azide free
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8°C. Following reconstitution store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: 3 month from despatch.
Expiry Date 3 months
Background publications Suda, Takahashi, Golstein et al.: "Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family." in: Cell, Vol. 75, Issue 6, pp. 1169-78, 1994 (PubMed).

Nagata, Golstein: "The Fas death factor." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1449-56, 1995 (PubMed).

Tanaka, Suda, Takahashi et al.: "Expression of the functional soluble form of human fas ligand in activated lymphocytes." in: The EMBO journal, Vol. 14, Issue 6, pp. 1129-35, 1995 (PubMed).

Stanley: "Autoantibodies against adhesion molecules and structures in blistering skin diseases." in: The Journal of experimental medicine, Vol. 181, Issue 1, pp. 1-4, 1995 (PubMed).

Tanaka, Suda, Haze et al.: "Fas ligand in human serum." in: Nature medicine, Vol. 2, Issue 3, pp. 317-22, 1996 (PubMed).

Sato, Kimura, Nakamura et al.: "An aggressive nasal lymphoma accompanied by high levels of soluble Fas ligand." in: British journal of haematology, Vol. 94, Issue 2, pp. 379-82, 1996 (PubMed).

Hosts (116), (81), (59), (24), (5), (1)
Reactivities (206), (127), (57), (18), (6), (3), (3), (1), (1)
Applications (157), (116), (81), (56), (40), (37), (22), (21), (18), (13), (10), (6), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1)
Conjugates (31), (13), (13), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (15), (6), (5), (4), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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