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FASL antibody (Fas Ligand (TNF Superfamily, Member 6))

Details for Product anti-FASL Antibody No. ABIN263613, Supplier: Log in to see
Antigen
  • ALPS1B
  • APT1LG1
  • Apt1Lg1
  • APTL
  • CD95-L
  • CD95L
  • CD178
  • FAS
  • Fas-L
  • FASL
  • fasl
  • Fasl
  • Faslg
  • FASLG
  • gld
  • TNFRSF6
  • Tnfsf6
  • TNFSF6
  • zgc:162027
Alternatives
anti-Human FASL antibody for Flow Cytometry
Reactivity
Human
269
132
65
3
1
1
1
1
1
1
Host
Hamster
143
123
59
30
6
6
Clonality (Clone)
Monoclonal ()
Conjugate
This FASL antibody is un-conjugated
31
24
17
4
3
3
3
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Functional Studies (Func), Flow Cytometry (FACS)
200
158
88
63
56
49
29
26
17
12
11
11
10
5
3
3
2
2
1
1
1
1
1
1
1
Supplier
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Immunogen Recombinant human Fas ligand. Hybridization of P3U1 myeloma Hamster lymphocytes.
Clone 4A5
Isotype IgG
Specificity This antibody reacts with FasL specifically.
Characteristics Synonyms: FASLG, APT1LG1, FASL, TNFSF6, CD95L protein, APTL, Tumor necrosis factor ligandsuperfamily member 6, Fas antigen ligand, Apoptosis antigen ligand
Alternative Name CD178 / Fas Ligand (FASL Antibody Abstract)
Background Apoptosis or programmed-cell death is a physiological process essential for the normal development and maintenance or homeostasis in many organisms. This cellular suicide can be triggered by the interaction of two cell-surface molecules, the Fas antigen (CD95) and its ligand, the Fas ligand or FasL. The FasL is a type II membrane protein of M, 40 kDa and is a member of the tumor necrosis factor (TNF) family. It is expressed by activated T cells. A 26 kDa soluble form of human FasL (sFasL) exists and has been detected in the supernatant of human peripheral NK cells and lymphocytes upon activation.Synonyms: APT1LG1, APTL, Apoptosis antigen ligand, CD95L protein, FASL, FASLG, Fas antigen ligand, TNFSF6, Tumor necrosis factor ligand superfamily member 6
Gene ID 356
UniProt P48023
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Apoptosis, EGFR Signaling Pathway
Application Notes Flow cytometry: Recommended: 10g/mL as a final concentration. ELISA. Neutralization of soluble Fas ligand cytotoxic-activity.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Reconstitution Restore with 100 μL of distilled water.
Buffer Lyophilized from PBS containing 1 % sucrose
Preservative Azide free
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: 3 month from despatch.
Expiry Date 3 months
Background publications Tanaka, Suda, Haze, Nakamura, Sato, Kimura, Motoyoshi, Mizuki, Tagawa, Ohga, Hatake, Drummond, Nagata: "Fas ligand in human serum." in: Nature medicine, Vol. 2, Issue 3, pp. 317-22, 1996 (PubMed).

Sato, Kimura, Nakamura, Murakami, Yoshida, Tanaka, Nagata, Kanatani, Wakimoto, Nagata, Motoyoshi: "An aggressive nasal lymphoma accompanied by high levels of soluble Fas ligand." in: British journal of haematology, Vol. 94, Issue 2, pp. 379-82, 1996 (PubMed).

Stanley: "Autoantibodies against adhesion molecules and structures in blistering skin diseases." in: The Journal of experimental medicine, Vol. 181, Issue 1, pp. 1-4, 1995 (PubMed).

Nagata, Golstein: "The Fas death factor." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1449-56, 1995 (PubMed).

Tanaka, Suda, Takahashi, Nagata: "Expression of the functional soluble form of human fas ligand in activated lymphocytes." in: The EMBO journal, Vol. 14, Issue 6, pp. 1129-35, 1995 (PubMed).

Suda, Takahashi, Golstein, Nagata: "Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family." in: Cell, Vol. 75, Issue 6, pp. 1169-78, 1994 (PubMed).