Microtubule-Associated Protein tau (MAPT) (pThr231) antibody

Details for Product No. ABIN264003
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Antigen
Synonyms tau, xtp, MAPT, AI426939, AI551861, AW457082, CK1epsilon, CKIe, KC1epsilon, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU, AI413597, AW045860, Mtapt, Tau, PHF-tau, RNPTAU, pTau
Epitope
pThr231
(44), (33), (33), (30), (30), (30), (29), (26), (26), (26), (25), (25), (24), (23), (18), (13), (12), (11), (11), (11), (11), (10), (10), (10), (9), (9), (9), (8), (8), (8), (8), (8), (7), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(859), (451), (428), (52), (8), (6), (3), (3), (2), (1), (1), (1), (1), (1)
Host
Mouse
(802), (95), (10), (8), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(10), (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(795), (346), (238), (91), (76), (60), (31), (30), (16), (13), (13), (13), (12), (9), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN264003
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Clone PHF6
Isotype IgG1
Characteristics Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein,Paired helical filament-tau
Purification Protein A chromatography
Alternative Name MAPT / tau
Background Tau is a neuronal microtubule associated protein found predominantly on axons. Thefunction of Tau is to promote tubulin polymerisation and stabilise microtubules, but it alsoserves to link certain signalling pathways to the cytoskeleton. Tau, in itshyperphosphorylated form, is the major component of paired helical filaments (PHF) andneurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs themicrotubule binding function of Tau, resulting in the destabilisation of microtubules in ADbrains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous systemdisorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, andcasein kinase II can phosphorylate Tau.
UniProt P10636
Research Area Cytoskeleton
Application Notes ELISA. Western Blot. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS without preservatives
Preservative Without preservative
Storage -20 °C/-80 °C
Storage Comment Store the antibody undiluted at -20°C to -80°C. Avoid repeated freezing and thawing. Do not store antibody diluted below 50 µg/ml in the absence of protein (i. e. add 2% BSA). Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Bramblett, Trojanowski, Lee: "Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins)." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 66, Issue 2, pp. 212-22, 1992 (PubMed).

Kosik, Orecchio, Binder et al.: "Epitopes that span the tau molecule are shared with paired helical filaments." in: Neuron, Vol. 1, Issue 9, pp. 817-25, 1990 (PubMed).

Bramblett, Goedert, Jakes et al.: "Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding." in: Neuron, Vol. 10, Issue 6, pp. 1089-99, 1993 (PubMed).

Hoffmann, Lee, Leight et al.: "Unique Alzheimer's disease paired helical filament specific epitopes involve double phosphorylation at specific sites." in: Biochemistry, Vol. 36, Issue 26, pp. 8114-24, 1997 (PubMed).

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