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Details for Product No. ABIN264011

Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) antibody

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Antigen
Synonyms Park, Prkn
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN264011
Quantity 0.2 mL
Price
676.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Clone Prk 8
Isotype IgG2b
Characteristics Synonyms: PRKN, E3 ubiquitin-protein ligase parkin, PDJ, AR-JP, LPRS2, Parkinson disease 2, Parkinsonjuvenile disease protein 2
Purification Protein A chromatography
Alternative Name PARK2 / Parkin
Background Parkinson's Disease, the second most common neurodegenerative disease afterAlzheimer's Disease, is characterized by the loss of dopaminergic neurons and thepresence of Lewy bodies (comprised of alpha synuclein and parkin inclusions). AutosomalRecessive Juvenile Parkinsonism (AR-JP) is a recently described form of Parkinson'sDisease that has been linked to a gene that codes for parkin. Parkin, a 52 kDa protein, hasa suggested role in the ubiquitin/proteasome pathway for protein degradation. The aminoterminus bears sequence homology to ubiquitin while functionally it acts as a RING typeubiquitin protein ligase (E3) that coordinates the transfer of ubiquitin to substrateproteins, thus targeting them for degradation by the proteasome.
UniProt O60260
Application Notes Western blot. ELISA. Immunohistochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS
Storage -20 °C
Storage Comment Store the antibody at -20°C. Avoid repeated freezing and thawing. Do not store antibody diluted below 50g/ml in the absence of protein (i. e. add 2% BSA). Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Pawlyk, Giasson, Sampathu et al.: "Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age." in: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 48120-8, 2003 (PubMed).

Alternatives for antigen "Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2)", type "Antibodies"
Hosts (73), (12), (7)
Reactivities (81), (16), (14), (5), (3), (2), (2)
Applications (74), (40), (24), (19), (9), (8), (6), (5), (4), (2), (1), (1), (1)
Conjugates (1)
Epitopes (10), (10), (9), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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