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SNCA antibody (Synuclein, alpha)

Details for Product anti-SNCA Antibody No. ABIN264097, Supplier: Log in to see
Antigen
  • snca
  • MGC64356
  • LOC619283
  • NACP
  • alphaSYN
  • PARK1
  • PARK4
  • PD1
  • synuclein, alpha
  • alpha-synuclein
  • synuclein, alpha (non A4 component of amyloid precursor)
  • snca
  • LOC619283
  • LOC100359228
  • Snca
  • SNCA
Reactivity
Human
619
266
261
16
14
11
11
8
4
2
2
2
1
1
1
Host
Mouse
405
197
35
10
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This SNCA antibody is un-conjugated
27
26
21
11
11
6
6
6
6
6
6
6
5
5
5
5
5
5
4
4
4
4
4
4
4
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
469
254
149
124
99
67
52
22
22
21
16
10
8
7
3
2
2
2
1
1
1
1
Options
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Immunogen Purified E. coli produced Human alpha-synuclein
Clone 4D6
Isotype IgG1
Specificity This antibody recognizes alpha-Synuclein.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Characteristics Synonyms: NACP, PARK1, Non-A beta component of AD amyloid, Non-A4 component of amyloidprecursor
Purification Protein A Chromatography.
Alternative Name alpha-Synuclein / SNCA (SNCA Antibody Abstract)
Background Synuclein-alpha is the major component of Lewy bodies and Lewy neuritis in sporadic PD. dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20 kDa) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma-synuclein and synoretin. The expression is abundant in neurons and typically localized at presynaptic terminals.Synonyms: NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Gene ID 6622
UniProt P37840
Research Area Neurology
Application Notes ELISA. Western/Dot Blot: 1/100-1/10,000. Immunohistochemistry on Frozen and Formalin-Fixed Paraffin Embedded Tissues: 1/100-1/1,000 (No formic acid, enzyme or HIER required).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS without preservatives.
Preservative Without preservative
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Trojanowski, Lee: "\' of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders." in: Annals of the New York Academy of Sciences, Vol. 924, pp. 62-7, 2001 (PubMed).

Lücking, Brice: "Alpha-synuclein and Parkinson's disease." in: Cellular and molecular life sciences : CMLS, Vol. 57, Issue 13-14, pp. 1894-908, 2001 (PubMed).

Conway, Lee, Rochet, Ding, Harper, Williamson, Lansbury: "Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 42-5, 2001 (PubMed).

Kahle, Neumann, Ozmen, Haass: "Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 33-41, 2001 (PubMed).

Polymeropoulos: "Genetics of Parkinson's disease." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 28-32, 2001 (PubMed).

Spillantini, Goedert: "The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy." in: Annals of the New York Academy of Sciences, Vol. 920, pp. 16-27, 2001 (PubMed).

Munoz: "Stains for the differential diagnosis of degenerative dementias." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, Vol. 74, Issue 6, pp. 311-20, 2000 (PubMed).

Schulz, Dichgans: "Molecular pathogenesis of movement disorders: are protein aggregates a common link in neuronal degeneration?" in: Current opinion in neurology, Vol. 12, Issue 4, pp. 433-9, 1999 (PubMed).

Clayton, George: "Synucleins in synaptic plasticity and neurodegenerative disorders." in: Journal of neuroscience research, Vol. 58, Issue 1, pp. 120-9, 1999 (PubMed).