Integrin beta 2 (ITGB2) antibody (Biotin)

Details for Product No. ABIN264217
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Antigen
Synonyms ITGB2, 2E6, AI528527, Cd18, LAD, LCAMB, Lfa1, MF17, CD18, LFA-1, MAC-1, MFI7, AI256028, LTbetaR, Ltar, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFRrp, Tnfbr, Tnfrsf3, D12S370, LT-BETA-R, TNFR3, TNFRSF3
Reactivity
Human
(257), (168), (99), (61), (53), (46), (36), (24), (1)
Host
Mouse
(179), (114), (103), (2), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
(55), (39), (29), (14), (10), (7), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (1), (1), (1)
Application
Flow Cytometry (FACS)
(262), (136), (119), (63), (45), (41), (40), (40), (38), (27), (15), (6), (3), (3), (2)
Pubmed 4 references available
Quantity 100 tests
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN264217
286.00 $
Plus shipping costs $45.00

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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Clone 3EB
Isotype IgG1
Characteristics Synonyms: Integrin beta-2, MFI7, Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunitbeta, Complement receptor C3 subunit beta
Alternative Name CD18 / ITGB2
Background LFA-1 beta is a leukocyte adhesion receptor to (ICAM's) intercellular adhesion molecules. LFA-1 beta is on virtually all peripheral blood lymphocytes, 95,000 M. W. surface antigen.
UniProt P05107
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry. Monitoring of subsets in peripheral blood. Analysis of CTL-mediated cytotoxicity. Studies of transplantation rejection. Functional studies of cell adhesion molecules. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Protocol PBMC: Add 10 ul of MAB/10e6 PBMC in 100 ul PBS. Mix gently and incubate for 15 minutes at 2-8°C. Wash twice with PBS and analyze or fix with 0. 5% v/v of paraformaldehyde in PBS andanalyze.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.2% protein carrier and 0.08% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C. Do Not Freeze! Shelf life: One year from despatch.
Expiry Date 12 months
Background publications Loike, Sodeik, Cao et al.: "CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 3, pp. 1044-8, 1991 (PubMed).

Merrill, Slade, Weissmann et al.: "Two pathways of CD11b/CD18-mediated neutrophil aggregation with different involvement of protein kinase C-dependent phosphorylation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 8, pp. 2608-15, 1990 (PubMed).

Richter, Ng-Sikorski, Olsson et al.: "Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosolic free Ca2+." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 23, pp. 9472-6, 1991 (PubMed).

Anderson, Springer: "Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins." in: Annual review of medicine, Vol. 38, pp. 175-94, 1987 (PubMed).

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