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Integrin beta 2 antibody (ITGB2) (Biotin)

Details for Product anti-ITGB2 Antibody No. ABIN264217, Supplier: Log in to see
Antigen
  • ITGB2
  • 2E6
  • AI528527
  • Cd18
  • LAD
  • LCAMB
  • Lfa1
  • MF17
  • CD18
  • LFA-1
  • MAC-1
  • MFI7
  • AI256028
  • LTbetaR
  • Ltar
  • TNF-R-III
  • TNFCR
  • TNFR-RP
  • TNFR2-RP
  • TNFRrp
  • Tnfbr
  • Tnfrsf3
  • D12S370
  • LT-BETA-R
  • TNFR3
  • TNFRSF3
Alternatives
anti-Human Integrin beta 2 antibody for Functional Studies
Reactivity
Human
412
201
96
25
24
7
6
3
3
2
2
2
2
2
2
2
1
1
Host
Mouse
281
165
154
5
2
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Integrin beta 2 antibody is conjugated to Biotin
90
70
49
19
9
7
6
5
4
3
3
3
3
3
3
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS)
394
240
184
109
82
65
61
44
39
35
16
9
7
6
4
3
2
1
1
1
1
Supplier
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Clone 3EB
Isotype IgG1
Specificity This antibody detects human LFA-1 beta.
Characteristics Synonyms: Integrin beta-2, MFI7, Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunitbeta, Complement receptor C3 subunit beta
Alternative Name CD18 / ITGB2 (ITGB2 Antibody Abstract)
Background LFA-1 beta is a leukocyte adhesion receptor to (ICAM's) intercellular adhesion molecules. LFA-1 beta is on virtually all peripheral blood lymphocytes, 95,000 M.W. surface antigen.Synonyms: 95 subunit beta, Cell surface adhesion glycoproteins LFA-1/CR3/p150, Complement receptor C3 subunit beta, Integrin beta-2, MFI7
Gene ID 3689
UniProt P05107
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways NF-kappaB Signaling
Application Notes Flow Cytometry. Monitoring of subsets in peripheral blood. Analysis of CTL-mediated cytotoxicity. Studies of transplantation rejection. Functional studies of cell adhesion molecules.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Protocol PBMC: Add 10 ul of MAB/10e6 PBMC in 100 ul PBS. Mix gently and incubate for 15 minutes at 2-8°C. Wash twice with PBS and analyze or fix with 0. 5% v/v of paraformaldehyde in PBS andanalyze.
Restrictions For Research Use only
Buffer PBS containing 0.2 % protein carrier and 0.08 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. Do Not Freeze!
Shelf life: One year from despatch.
Expiry Date 12 months
Background publications Anderson, Springer: "Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins." in: Annual review of medicine, Vol. 38, pp. 175-94, 1987 (PubMed).

Richter, Ng-Sikorski, Olsson et al.: "Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosolic free Ca2+." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 23, pp. 9472-6, 1991 (PubMed).

Merrill, Slade, Weissmann et al.: "Two pathways of CD11b/CD18-mediated neutrophil aggregation with different involvement of protein kinase C-dependent phosphorylation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 8, pp. 2608-15, 1990 (PubMed).

Loike, Sodeik, Cao et al.: "CD11c/CD18 on neutrophils recognizes a domain at the N terminus of the A alpha chain of fibrinogen." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 3, pp. 1044-8, 1991 (PubMed).