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CD11b antibody (Integrin alpha M) (PE)

Details for Product anti-ITGAM Antibody No. ABIN264315, Supplier: Log in to see
Antigen
  • C3bi
  • CD11B
  • Cd11b
  • CD11b/CD18
  • CR3
  • CR3A
  • F730045J24Rik
  • Ly-40
  • MAC-1
  • Mac-1
  • Mac-1a
  • MAC1
  • MAC1A
  • MO1A
  • SLEB6
Alternatives
anti-Human CD11b antibody for Immunoprecipitation
Reactivity
Human
615
467
146
67
26
20
17
17
17
11
10
9
5
4
3
2
2
1
Host
Mouse
476
413
117
17
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This CD11b antibody is conjugated to PE
164
122
88
51
18
17
12
12
11
11
11
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2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
799
244
207
162
140
112
78
77
72
69
19
15
11
7
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4
3
3
3
3
3
2
1
1
1
1
1
1
1
Supplier
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Clone F6-2
Isotype IgG2a
Characteristics Synonyms: Integrin alpha-M, CR3A, MAC-1, MAC1, CR-3 alpha chain, Cell surface glycoprotein MAC-1subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11antigen-like family member B
Alternative Name CD11b (ITGAM Antibody Abstract)
Background (Mac-1), CD11b/CD18 complex is a leukocyte adhesion receptor to intercellular adhesion molecules (ICAM's). CR3 alpha chain (M.W. 165,000) is on virtually all peripheral blood neutrophils, eosinophils, monocytes and approximately 30 % of peripheral blood lymphocytes.Synonyms: CD11 antigen-like family member B, CR-3 alpha chain, CR3A, Cell surface glycoprotein MAC-1 subunit alpha, ITGAM, Integrin alpha-M, Leukocyte adhesion receptor MO1, MAC1, Neutrophil adherence receptor
Gene ID 3684
UniProt P11215
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, Glia marker, CD Antigens, Surface Receptors of Immune Cells
Pathways Apoptosis
Application Notes Flow Cytometry. Monitoring of subsets in peripheral blood. Characterization of leukemias and lymphomas. Analysis of CTL-mediated cytotoxicity. Studies of transplantation rejection. Functional studies of cell adhesion molecules.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Protocol PBMC: Add 10 ul of MAB/10e6 PBMC in 100 ul PBS. Mix gently and incubate for 15 minutes at 2-8°C. Wash twice with PBS and analyze or fix with 0. 5% v/v of paraformaldehyde in PBS andanalyze.
Restrictions For Research Use only
Buffer Sterile filtered PBS containing 0.2 % protein carrier and 0.08 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CD11b antibody (Integrin alpha M)  (PE) (ABIN264315) anti-Integrin alpha M (ITGAM) antibody (PE)
Background publications Richter, Ng-Sikorski, Olsson, Andersson: "Tumor necrosis factor-induced degranulation in adherent human neutrophils is dependent on CD11b/CD18-integrin-triggered oscillations of cytosolic free Ca2+." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 23, pp. 9472-6, 1991 (PubMed).

Babcock, Alexander, Warden: "Flow cytometric analysis of neutrophil subsets in thermally injured patients developing infection." in: Clinical immunology and immunopathology, Vol. 54, Issue 1, pp. 117-25, 1990 (PubMed).

Arnaout: "Structure and function of the leukocyte adhesion molecules CD11/CD18." in: Blood, Vol. 75, Issue 5, pp. 1037-50, 1990 (PubMed).

Merrill, Slade, Weissmann, Winchester, Buyon: "Two pathways of CD11b/CD18-mediated neutrophil aggregation with different involvement of protein kinase C-dependent phosphorylation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 8, pp. 2608-15, 1990 (PubMed).

Anderson, Springer: "Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins." in: Annual review of medicine, Vol. 38, pp. 175-94, 1987 (PubMed).