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Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase)

Details for Product anti-CASP6 Antibody No. ABIN264405, Supplier: Log in to see
Antigen
  • xCaspase-6
  • mch2
  • caspase-6
  • zgc:112960
  • CASP6
  • casp6
  • Mch2
  • mCASP-6
  • MCH2
Alternatives
anti-Human Caspase 6 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Reactivity
Human
271
82
77
15
3
2
Host
Mouse
269
19
15
Clonality (Clone)
Monoclonal ()
Conjugate
This Caspase 6 antibody is un-conjugated
19
18
14
11
11
11
4
3
3
3
3
3
3
3
3
Application
Western Blotting (WB)
248
152
106
51
35
24
22
13
9
6
5
1
1
Supplier
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Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman capase-6 protein and mouse myeloma cells. Genename: CASP6
Clone MCH2 14 1-190
Isotype IgG1
Specificity Detects proenzyme form of human Caspase-6 by Western blot.
Characteristics Synonyms: CASP-6, CASP6, MCH2, MCH-2, Apoptotic protease Mch-2
Purification Purified
Alternative Name Caspase-6 (CASP6 Antibody Abstract)
Background Caspase-6 (Cysteine-Requiring Aspartate Proteases) is part of a family of intracellular cysteine proteases that cleave their substrates after aspartic acid residues. These proteases play an integral role in inducing apoptosis in cells. Procaspase-6 (Mch2), a member of the ICE/ced-3 subfamily, is an inactive proenzyme that is activated to form caspase-6 by proteolytic cleavage at certain aspartic acid residues. During cleavage, the N-terminal is removed and the proenzyme is converted into a large (p18) and small (p11) subunits. Caspase-6 has two isoforms produced by alternative splicing. Over-expression of the isoform of caspase-6 without its prodomain can induce apoptosis. The isoform does not seem to display proteolytic activity. Together with caspases-3 and -7, the isoform of caspase-6 is classified as an effector/execution caspase. Caspase-3, caspase-8 and caspase-10 can cleave procaspase-6. Active caspase-6 cleaves several other proteins such as lamins, NuMa and Keratin 18. A possible cleavage of caspases-8 and -10 in cytochrome-C dependent apoptosis was reported recently.Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2
Gene ID 839
UniProt P55212
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes Western Blot. Positive Control: MCF-7 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.08 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (ABIN264405) anti-Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) antibody
Background publications Kidd: "Proteolytic activities that mediate apoptosis." in: Annual review of physiology, Vol. 60, pp. 533-73, 1998 (PubMed).

Hirata, Takahashi, Kobayashi et al.: "Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis." in: The Journal of experimental medicine, Vol. 187, Issue 4, pp. 587-600, 1998 (PubMed).

Orth, Chinnaiyan, Garg et al.: "The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A." in: The Journal of biological chemistry, Vol. 271, Issue 28, pp. 16443-6, 1996 (PubMed).

Fernandes-Alnemri, Litwack, Alnemri: "Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family." in: Cancer research, Vol. 55, Issue 13, pp. 2737-42, 1995 (PubMed).