Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody

Details for Product No. ABIN264409
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Antigen
Synonyms CASP9, AI115399, APAF-3, AW493809, CASP-9, Caspase-9, ICE-LAP6, Mch6, Apaf3, Casp-9-CTD, Casp9_v1, Ice-Lap6, APAF3, MCH6, PPP1R56
Reactivity
Human
(352), (122), (112), (17), (16), (12), (11), (6), (3), (3), (1), (1), (1), (1)
Host
Mouse
(368), (30), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1)
Application
Western Blotting (WB)
(347), (157), (97), (71), (68), (50), (42), (33), (12), (10), (5), (4), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN264409
324.50 $
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Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman capase-9 protein and mouse myeloma cells. Genename: CASP9
Clone LAP6 96-2-22
Isotype IgG
Specificity Detects Proenzyme form of Human Caspase-9 by Western blot analysis as well as one of the cleavage products after treatment with thapsigargin.
Characteristics Synonyms: CASP-9, CASP9, MCH6, ICE-LAP6, APAF-3, APAF3, ICE-like apoptotic protease 6, Apoptoticprotease Mch-6, Apoptotic protease-activating factor 3
Purification Purified
Alternative Name Caspase-9
Background Caspases are key effectors of programmed cell death. They are synthesized as inactive proenzymes which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker which may be involved in the regulation of the different caspases. Caspase-9 is a member of the CED-3 family and bear high similarity to caspase-3. Procaspase-9 can be activated by either caspase-3 or granzyme B, although they cleave the proenzyme to different size subunits. Cleavage by granzyme B produces an active enzyme which is capable of cleaving PARP. Also, the ability of caspase-3 to activate caspase-9 seems to suggest that caspase-9 is further downstream of caspase-3 and may be involved in later changes in cells observed undergoing apoptosis.Synonyms: APAF-3, APAF3, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, CASP-9, CASP9, ICE-LAP6, ICE-like apoptotic protease 6, MCH6
Gene ID 842
UniProt P55211
Research Area Apoptosis/Necrosis, Cancer
Application Notes Western Blot. Positive Control: MCF-7 cell lines.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.08 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Expiry Date 12 months
Supplier Images
anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody
Background publications Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).

Stennicke, Deveraux, Humke et al.: "Caspase-9 can be activated without proteolytic processing." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8359-62, 1999 (PubMed).

Kuida: "Caspase-9." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 2, pp. 121-4, 2000 (PubMed).

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