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Caspase 9 antibody (Caspase 9, Apoptosis-Related Cysteine Peptidase)

Details for Product anti-CASP9 Antibody No. ABIN264409, Supplier: Log in to see
Antigen
  • CASP9
  • AI115399
  • APAF-3
  • AW493809
  • CASP-9
  • Caspase-9
  • ICE-LAP6
  • Mch6
  • Apaf3
  • Casp-9-CTD
  • Casp9_v1
  • Ice-Lap6
  • APAF3
  • MCH6
  • PPP1R56
Alternatives
anti-Human Caspase 9 antibody for Western Blotting
Reactivity
Human
396
111
107
15
13
9
6
5
3
3
2
1
1
1
Host
Mouse
404
44
1
Clonality (Clone)
Monoclonal ()
Conjugate
This Caspase 9 antibody is un-conjugated
11
10
7
5
4
4
4
4
4
4
4
4
3
3
3
Application
Western Blotting (WB)
373
159
114
65
64
57
46
30
13
9
6
6
2
2
Supplier
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Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinanthuman capase-9 protein and mouse myeloma cells. Genename: CASP9
Clone LAP6 96-2-22
Isotype IgG
Specificity Detects Proenzyme form of Human Caspase-9 by Western blot analysis as well as one of the cleavage products after treatment with thapsigargin.
Characteristics Synonyms: CASP-9, CASP9, MCH6, ICE-LAP6, APAF-3, APAF3, ICE-like apoptotic protease 6, Apoptoticprotease Mch-6, Apoptotic protease-activating factor 3
Purification Purified
Alternative Name Caspase-9 (CASP9 Antibody Abstract)
Background Caspases are key effectors of programmed cell death. They are synthesized as inactive proenzymes which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker which may be involved in the regulation of the different caspases. Caspase-9 is a member of the CED-3 family and bear high similarity to caspase-3. Procaspase-9 can be activated by either caspase-3 or granzyme B, although they cleave the proenzyme to different size subunits. Cleavage by granzyme B produces an active enzyme which is capable of cleaving PARP. Also, the ability of caspase-3 to activate caspase-9 seems to suggest that caspase-9 is further downstream of caspase-3 and may be involved in later changes in cells observed undergoing apoptosis.Synonyms: APAF-3, APAF3, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, CASP-9, CASP9, ICE-LAP6, ICE-like apoptotic protease 6, MCH6
Gene ID 842
UniProt P55211
Research Area Apoptosis/Necrosis, Cancer
Pathways MAPK Signaling, RTK Signaling, Apoptosis, Caspase Cascade in Apoptosis, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Western Blot. Positive Control: MCF-7 cell lines.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.08 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Caspase 9 antibody (Caspase 9, Apoptosis-Related Cysteine Peptidase) (ABIN264409) anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody
Background publications Kuida: "Caspase-9." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 2, pp. 121-4, 2000 (PubMed).

Stennicke, Deveraux, Humke et al.: "Caspase-9 can be activated without proteolytic processing." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8359-62, 1999 (PubMed).

Cohen: "Caspases: the executioners of apoptosis." in: The Biochemical journal, Vol. 326 ( Pt 1), Issue 5693, pp. 1-16, 1997 (PubMed).