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Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (AA 1-213), (N-Term) antibody

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Synonyms Vhlh, HRCA1, RCA1, VHL1, pVHL
AA 1-213, N-Term
(19), (14), (9), (7), (5), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1)
(101), (45), (40), (4), (1), (1)
(62), (23), (16)
Clonality (Clone)
Monoclonal ()
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(71), (51), (31), (16), (11), (8), (8), (5), (2), (1), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with arecombinant fusion protein containing amino acids 1-213 of human VHL and mousemyeloma p3-NS-1/Ag4-1 cells.
Clone Ig33
Isotype IgG1
Characteristics Synonyms: Von Hippel-Lindau disease tumor suppressor, Protein G7
Purification Purified
Alternative Name VHL (VHL Antibody Abstract)
Background Alterations in the von Hippel-Lindau (VHL) gene are correlated with a diverse group of neoplasms including hemangioblastoma, clear cell renal carcinoma (RCC), and pheochromocytoma. Molecular genetic studies suggest that VHL is a tumor-suppressor gene, correspondingly, reintroduction of a VHL complementary DNA (cDNA) into RCC cells inhibits their ability to form tumors in nude mice. Two transcriptional elongation factors, Elongin B and C, are shown to bind in vitro and in vivo to a short, colinear region of the VHL protein (pVHL) that is frequently mutated in human tumors. It is proposed that pVHL functions in vivo as a negative regulator of transcription elongation.Synonyms: Protein G7, Von Hippel-Lindau disease tumor suppressor
UniProt P40337
Research Area Hormones, Cytokines
Application Notes Western Blot (1 μg/mL). Immunoprecipitation (2 μg/mg of protein lysate). Immunohistochemistry on frozen and Formalin/paraffin embedded tissues (2-4 μg/mL). Positive Control: Carcinomas of kidney, lung, prostate, colon, breast, bladder and thyroid,cerebellar hemagioblastomas and pheochromocytoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1,0 mg/mL
Buffer PBS containing 0.08 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (AA 1-213), (N-Term) antibody (ABIN264443) anti-Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL) (AA 1-213), (N-Term) antibody
Background publications Corless, Kibel, Iliopoulos et al.: "Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues." in: Human pathology, Vol. 28, Issue 4, pp. 459-64, 1997 (PubMed).

Los, Jansen, Kaelin et al.: "Expression pattern of the von Hippel-Lindau protein in human tissues." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 75, Issue 2, pp. 231-8, 1996 (PubMed).

Kibel, Iliopoulos, DeCaprio et al.: "Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C." in: Science (New York, N.Y.), Vol. 269, Issue 5229, pp. 1444-6, 1995 (PubMed).

Iliopoulos, Kibel, Gray et al.: "Tumour suppression by the human von Hippel-Lindau gene product." in: Nature medicine, Vol. 1, Issue 8, pp. 822-6, 1995 (PubMed).

Catalog No. ABIN264443
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