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Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody

Details for Product No. ABIN264477
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Antigen
Synonyms
CXC-R4, CXCR-4, cd184, d2s201e, fb22, hm89, hsy3rr, lap3, lcr1, lestr, npy3r, npyr, npyrl, npyy3r, whim, xcxcr4, cxcr4, CD184, Cmkar4, LESTR, PB-CKR, PBSF/SDF-1, Sdf1r, D2S201E, FB22, HM89, HSY3RR, LA ... show more
CXC-R4, CXCR-4, cd184, d2s201e, fb22, hm89, hsy3rr, lap3, lcr1, lestr, npy3r, npyr, npyrl, npyy3r, whim, xcxcr4, cxcr4, CD184, Cmkar4, LESTR, PB-CKR, PBSF/SDF-1, Sdf1r, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, CXC-R4-B, CXCR-4-B, CXCR4, cb403, zgc:109863 show less
Reactivity
Chimpanzee, Human, Monkey
(218), (112), (66), (29), (13), (12), (3), (2), (1), (1), (1)
Host
Mouse
(180), (39), (20), (13), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(163), (77), (76), (59), (37), (29), (28), (27), (24), (8), (6), (6), (4), (1), (1), (1)
Pubmed 3 references available
Quantity 0.5 mg
Shipping to United States (Change)
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Catalog No. ABIN264477
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Immunogen SIV-infected SupT1 cells injected into Balb/c mice.
Clone 12G5
Isotype IgG1
Characteristics Synonyms: CXC-R4, CXCR-4, Fusin, LCR1, FB22, NPYRL, HM89, SDF1 receptor, LESTR, C-X-C chemokinereceptor type 4, Stromal cell-derived factor 1 receptor, Leukocyte-derived seventransmembrane domain receptor
Purification Affinity Chromatography.
Alternative Name CD184 / CXCR4
Background A receptor for the C-X-C chemokine CXCL12/SDF-1, CXCR4 transduces a signal by increasingthe intracellular calcium ions level. It is involved in haematopoiesis and in cardiacventricular septum formation. Also plays an essential role in vascularization of thegastrointestinal tract, probably by regulating vascular branching and/or remodellingprocesses in endothelial cells. Could be involved in cerebellar development. In the CNS,could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primaryreceptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. PromotesEnv-mediated fusion of the virus. Clone 12G5 has been shown to block infection by certainisolates of HIV-1 and HIV-2 and is specific for CXCR4 and does not react with IL8R-A, CCR1,CCR2b, CCR3, CCR4, and CCR5. CXCR4 is upregulated in response to activation of PBMCsfor 3-5 days with PHA.
UniProt P61073
Research Area CD Antigens, Surface Receptors of Immune Cells, Chemokines, Receptors
Application Notes Flow CytometryImmunofluorescence. Immunocytochemistry. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections ( 10 µg/ml). Immunohistochemical analyses of the CXCR4 receptor in Human cell lines and tissues. Fixation with methanol and/or acetone was shown to destroy the epitope of the 12G5 mAb.12G5 can be used to block SDF-1-induced chemotaxis and increases of intracellularcalcium. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS, pH 7.3
Storage -20 °C
Storage Comment The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody anti-Chemokine (C-X-C Motif) Receptor 4 (CXCR4) antibody
Background publications Endres, Clapham, Marsh et al.: "CD4-independent infection by HIV-2 is mediated by fusin/CXCR4." in: Cell, Vol. 87, Issue 4, pp. 745-56, 1997 (PubMed).

Bleul, Wu, Hoxie et al.: "The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 5, pp. 1925-30, 1997 (PubMed).

Yoshino, Ami, Terao et al.: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000 (PubMed).

Validation Images
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