TIMP2 antibody

Catalog No. ABIN264510

Product Details anti-TIMP2 Antibody

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Reactivity: Human, Mouse, Zebrafish (Danio rerio), Rabbit, Pig, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This TIMP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Matrix Metalloproteinase 2 (TIMP2).

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rabbit, Chicken, Zebrafish, Pig.
Species reactivity (tested):Human.

Characteristics: Synonyms: TIMP-2, Tissue inhibitor of metalloproteinases 2, Metalloproteinase inhibitor 2, CSC-21K

Purification: Purified

Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with asynthetic peptide derived from the human TIMP-2 protein and mouse myeloma Ag8563cells. Sequence common in mouse, rabbit, chicken, zebrafish and pig.

Clone: 3A4

Isotype: IgG2a

Application Details

Application Notes: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections: 1 - 5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,95 mg/mL

Buffer: PBS, 0.08 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for TIMP2

Target: TIMP2 (Metalloproteinase Inhibitor 2 (TIMP2))

Alternative Name: TIMP2 (TIMP2 Products)

Synonyms: CSC-21K antibody, DDC8 antibody, timp2l antibody, zgc:65967 antibody, zgc:85799 antibody, D11Bwg1104e antibody, Timp-2 antibody, TIMP-2 antibody, etID32613.12 antibody, fa96h09 antibody, timp2 antibody, wu:fa96h09 antibody, zgc:136726 antibody, TIMP metallopeptidase inhibitor 2 antibody, TIMP metallopeptidase inhibitor 2b antibody, tissue inhibitor of metalloproteinase 2 antibody, TIMP metallopeptidase inhibitor 2a antibody, TIMP metallopeptidase inhibitor 2 L homeolog antibody, TIMP2 antibody, timp2b antibody, Timp2 antibody, timp2a antibody, timp2.L antibody

Background: TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases-1, -2, -3 and -4) complex with metalloproteinases such as collagenases,gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 was found to be identical to EPA (erythroidpotentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation,branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart and low levels of TIMP-4 are expressed in liver, brain, lung, thymus and spleen.Synonyms: CSC-21K, Metalloproteinase inhibitor 2, TIMP-2, Tissue inhibitor of metalloproteinases 2

Molecular Weight: 18.5-21 kDa

Gene ID: 7077

UniProt: P16035

Pathways: cAMP Metabolic Process