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SERPINB9 antibody (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9)

Details for Product anti-SERPINB9 Antibody No. ABIN264518, Supplier: Log in to see
Antigen
  • BB283241
  • CAP-3
  • CAP3
  • ovalbumin
  • PI-9
  • PI9
  • SERPINB9
  • Spi6
Reactivity
Human
109
15
14
2
1
Host
Mouse
51
42
16
1
Clonality (Clone)
Monoclonal ()
Conjugate
This SERPINB9 antibody is un-conjugated
4
3
3
3
3
3
2
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
94
42
31
30
29
16
4
2
1
1
1
Supplier
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Immunogen Hybridoma produced by the fusion of splenocytes from mice immunized with recombinantPI-9 produced in P. pastoris and mouse myeloma cells.
Clone 7D8
Isotype IgG1
Specificity This antibody reacts to PI-9 / SERPINB9.
Characteristics Synonyms: PI9, Serpin B9, Cytoplasmic antiproteinase 3, CAP-3, CAP3, Proteinase inhibitor 9
Purification Purified
Alternative Name SERPINB9 (SERPINB9 Antibody Abstract)
Background This antibody detects the human intracellular serpin, PI 9, which is present in cytotoxic and dendritic cells to protect against the proapoptotic protease, granzyme B. Pi 9 may be unregulated by tumours to evade the immune system.Synonyms: CAP-3, CAP3, Cytoplasmic antiproteinase 3, PI-9, PI9, Proteinase inhibitor 9, Serpin B9
Gene ID 5272
UniProt P50453
Research Area Proteases
Application Notes Flow cytometry. Immunohistochemistry (frozen & paraffin*). Western Blot. Positive Control: Found in the cytoplasm.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Hirst, Buzza, Bird, Warren, Cameron, Zhang, Ashton-Rickardt, Bird: "The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 805-15, 2003 (PubMed).

Hirst, Buzza, Sutton, Trapani, Loveland, Bird: "Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction." in: Molecular human reproduction, Vol. 7, Issue 12, pp. 1133-42, 2001 (PubMed).

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