Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) antibody

Details for Product No. ABIN264523
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Antigen
Synonyms AI323664, BB161688, SLP-76, SLP76, twm, Slp76
Reactivity
Human
(110), (41), (35), (17), (14), (14)
Host
Mouse
(83), (19), (9), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Immunoprecipitation (IP), Western Blotting (WB)
(83), (34), (30), (26), (23), (8), (4), (4), (3), (2), (2)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN264523
324.50 $
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Immunogen Recombinant human SLP-76 fusion protein
Clone AS55
Isotype IgG2a
Characteristics Synonyms: LCP2, Lymphocyte cytosolic protein 2, SLP-76 tyrosine phosphoprotein, SLP76, SH2domain-containing leukocyte protein of 76 kDa
Purification Protein G Chromatography
Purity > 95 % by SDS-PAGE
Alternative Name LCP2
Background SLP76 (SH2 domain containing leukocyte protein of 76 kDa) is a hematopoieticcell-specific adaptor protein that is crucial for T-cell receptor (TCR) signaling, hemostasisand platelet function. TCR ligation and fibrinogen binding to integrin alpha 2 beta 3stimulates the phosphorylation of the tyrosine residues in the amino terminus, andfacilitates SLP76 binding to the SH2 domain of Vav, which can activate JNK. SLP76 alsocomprises a proline-rich domain region that associates with the SH3 domain of Grb2linking SLP76 to the Ras to Raf to ERK1 & 2 signaling pathway, LAT, PLC gamma,Fyn-binding protein (SLAP130), the SH2 containing phosphatase 1 and Nck, whichmediates the regulation of cytoskeletal actin polymerization. Phosphorylation of tyrosine145 has been shown to be important for optimal SLP76 function.
UniProt Q13094
Research Area Signaling
Application Notes Western Blot: 1g/ml to visualize 1 x 10e5 Jurkat cells per lane. Immunoprecipitation: 1 to 5 g per 1 x 10e6 Jurkat cells. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline with 0.1% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) antibody anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) antibody
Background publications Jackman, Motto, Sun et al.: "Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells." in: The Journal of biological chemistry, Vol. 270, Issue 13, pp. 7029-32, 1995 (PubMed).

Bubeck Wardenburg, Fu, Jackman et al.: "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function." in: The Journal of biological chemistry, Vol. 271, Issue 33, pp. 19641-4, 1996 (PubMed).

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