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Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) antibody

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Synonyms AI323664, BB161688, SLP-76, SLP76, twm, Slp76
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(133), (56), (42), (10), (4), (3), (1), (1), (1)
(79), (38), (21)
Clonality (Clone)
Monoclonal ()
(3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Immunoprecipitation (IP), Western Blotting (WB)
(109), (39), (29), (23), (15), (11), (8), (7), (5), (4), (2), (2), (1)
Pubmed 2 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant human SLP-76 fusion protein
Clone AS55
Isotype IgG2a
Specificity Recognizes human SH2 (Src homology 2) domain-Leukocyte Protein of 76 kDa.
Characteristics Synonyms: LCP2, Lymphocyte cytosolic protein 2, SLP-76 tyrosine phosphoprotein, SLP76, SH2domain-containing leukocyte protein of 76 kDa
Purification Protein G Chromatography
Purity > 95 % by SDS-PAGE
Alternative Name LCP2 (LCP2 Antibody Abstract)
Background SLP76 (SH2 domain containing leukocyte protein of 76 kDa) is a hematopoietic cell-specific adaptor protein that is crucial for T-cell receptor (TCR) signaling, hemostasis and platelet function. TCR ligation and fibrinogen binding to integrin alpha 2 beta 3 stimulates the phosphorylation of the tyrosine residues in the amino terminus, and facilitates SLP76 binding to the SH2 domain of Vav, which can activate JNK. SLP76 also comprises a proline-rich domain region that associates with the SH3 domain of Grb2 linking SLP76 to the Ras to Raf to ERK1 & 2 signaling pathway, LAT, PLC gamma, Fyn-binding protein (SLAP130), the SH2 containing phosphatase 1 and Nck, which mediates the regulation of cytoskeletal actin polymerization. Phosphorylation of tyrosine 145 has been shown to be important for optimal SLP76 function.Synonyms: LCP2, Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76
Gene ID 3937
UniProt Q13094
Research Area Signaling
Pathways Fc-epsilon Receptor Signaling Pathway
Application Notes Western Blot: 1g/mL to visualize 1 x 10e5 Jurkat cells per lane. Immunoprecipitation: 1 to 5 g per 1 x 10^6 Jurkat cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline with 0.1 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Western Blotting (WB) image for anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) antibody (ABIN264523) anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) antibody
Background publications Bubeck Wardenburg, Fu, Jackman et al.: "Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function." in: The Journal of biological chemistry, Vol. 271, Issue 33, pp. 19641-4, 1996 (PubMed).

Jackman, Motto, Sun et al.: "Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells." in: The Journal of biological chemistry, Vol. 270, Issue 13, pp. 7029-32, 1995 (PubMed).

Catalog No. ABIN264523
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