Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5) (N-Term) antibody

Details for Product No. ABIN264543
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Antigen
Synonyms ICE(rel)III, ICEREL-III, ICH-3, CASP5
Epitope
N-Term
(10), (10), (8), (8), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(81), (15), (15), (14), (11), (11), (3), (3), (3)
Host
Rabbit
(78), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(73), (34), (13), (11), (10), (10), (9), (5), (2), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN264543
478.50 $
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Immunogen 16 amino acid peptide from near the amino-terminus of human Caspase-5
Specificity This antibody reacts to Caspase-5, N-terminal. Depending on cell lines or tissues used, other cleavage products may be observed.
Purification Immunoaffinity chromatography
Alternative Name Caspase-5
Background Caspase 5 belongs to the Ced3/ICE family of cystein proteases and is an upstream Caspase with a long prodomain. It undergoes a cleavage upon activation, leading to p20 and p10 subunits which have high homology with several other Caspases over the equivalent coding sequences.
Alternate names: CASP-5, CASP5, ICE(rel)-III, ICH-3 protease, ICH3, TY protease
Gene ID 838
NCBI Accession NP_001129581
UniProt P51878
Research Area Apoptosis/Necrosis
Application Notes Western Blot: 1,0 ug/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Kuida, Lippke, Ku et al.: "Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme." in: Science (New York, N.Y.), Vol. 267, Issue 5206, pp. 2000-3, 1995 (PubMed).

Martinon, Burns, Tschopp: "The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta." in: Molecular cell, Vol. 10, Issue 2, pp. 417-26, 2002 (PubMed).

Gracie, Robertson, McInnes: "Interleukin-18." in: Journal of leukocyte biology, Vol. 73, Issue 2, pp. 213-24, 2003 (PubMed).

Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, 2004 (PubMed).

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