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CD209 Molecule (CD209) (AA 277-293) antibody

Details for Product No. ABIN264567
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Antigen
Synonyms cd209, CLEC4M, DC-SIGN, si:ch211-224h1.3, CDSIGN, CLEC4L, DC-SIGN1, CD209, CIRE, Dcsign, SIGN-R1, SIGNR5, Cd209
Epitope
AA 277-293
(25), (7), (6), (4), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1)
Reactivity
Human
(212), (52), (17), (1)
Host
Rabbit
(120), (102), (47)
Clonality
Polyclonal
Conjugate
Un-conjugated
(32), (18), (18), (17), (16), (10), (8), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(150), (95), (38), (36), (32), (32), (27), (25), (13), (13), (5), (3), (1)
Pubmed 7 references available
Quantity 0.1 mg
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Catalog No. ABIN264567
544.50 $
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Immunogen Synthetic peptide corresponding to amino acids 277-293 of human DC-SIGN
Sequence CYFMSNSQRN WHDSITA
Specificity This antibody reacts with DC-SIGN (Dendritic Cell-specific ICAM-3 Grabbing Non-integrin) Extracellular domain. The expression of DC-SIGN is found in mucosal tissues including placenta, small intestine and rectum.
Purification Immunoaffinity purified
Alternative Name CD209 / DC-SIGN
Background Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV1, HIV2 and SIV bind to DCs via DCSIGN. ICAM3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed CD299, DC-SIGNR, L-SIGN and DCSIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
Alternate names: C-type lectin domain family 4 member L, CLEC4L, DC-SIGN1, DCSIGN, DCSIGN1, Dendritic Cell Marker, Dendritic cell-specific ICAM-3-grabbing non-integrin 1
NCBI Accession 9606
UniProt Q9NNX6
Research Area CD Antigens
Application Notes Immunohistochemistry: 10g/ml. Western Blot: 1 - 2g/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5mg/mL
Buffer PBS containing 0.02% Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Geijtenbeek, Torensma, van Vliet et al.: "Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses." in: Cell, Vol. 100, Issue 5, pp. 575-85, 2000 (PubMed).

Geijtenbeek, Kwon, Torensma et al.: "DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells." in: Cell, Vol. 100, Issue 5, pp. 587-97, 2000 (PubMed).

Soilleux, Barten, Trowsdale: "DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 6, pp. 2937-42, 2000 (PubMed).

Pöhlmann, Soilleux, Baribaud et al.: "DC-SIGNR, a DC-SIGN homologue expressed in endothelial cells, binds to human and simian immunodeficiency viruses and activates infection in trans." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 5, pp. 2670-5, 2001 (PubMed).

Mummidi, Catano, Lam et al.: "Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts." in: The Journal of biological chemistry, Vol. 276, Issue 35, pp. 33196-212, 2001 (PubMed).

Mitchell, Fadden, Drickamer: "A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands." in: The Journal of biological chemistry, Vol. 276, Issue 31, pp. 28939-45, 2001 (PubMed).

Barbeau, Cano-Soumillac, Griffin et al.: "Quinolinone and pyridopyrimidinone inhibitors of DNA-dependent protein kinase." in: Organic & biomolecular chemistry, Vol. 5, Issue 16, pp. 2670-7, 2007 (PubMed).

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