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Antibodies
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anti-Death Effector Domain Containing 2 (DEDD2) antibody
Death Effector Domain Containing 2 (DEDD2) antibody
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| Synonyms |
FLAME-3, DEDD2, MGC140424, MGC145883, DEFT, KE05, DEDD1, FLDED1, CASP8IP1, 2410050E11Rik, DEDD, MGC127710, DKFZp459K109 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Application
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| Catalog no. |
ABIN264570 |
| Quantity |
0.1 mg (Variants) |
| Price |
410.00 $ Plus shipping costs $35.00
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| Shipping to |
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| Availability |
Ships within 7 to 10 Business Days |
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Characteristics
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Synonyms: FLAME3, FLAME-3, PSEC0004, FADD-like anti-apoptotic molecule 3, DEDD-2, DNA-bindingdeath effector domain-containing protein 2, DED-containing protein FLAME-3
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Alternative name
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DEDD2
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Swiss-Prot
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Q8WXF8
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Immunogen
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Synthetic peptide corresponding to 11 amino acids near the amino terminus of HumanDEDD2
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Cross-Reactivity
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Human, Mouse (Murine), Rat (Rattus)
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Description
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Apoptotic signals are often triggered by cell surface death receptors throughprotein-protein interactions mediated by conserved domains such as the death effectordomain. A novel death effector domain (DED)-containing protein, DEDD2, has been recentlyidentified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis andresults in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. Morerecently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP butnot FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to thenucleus upon induction of apoptosis, and it has been suggested that DEDD2 may targetcaspase-8 to the nucleus and that DEDD2 thus plays a critical role in deathreceptor-induced apoptosis. At least two alternatively spliced transcript variants encodingdistinct isoforms have been found for DEDD2.
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Specificity
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This antibody reacts to DEDD 2. Species: Human, Mouse, Rat. Others not tested.
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Application Notes
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Western Blot: 0.5 - 1,0 ug/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Purification
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Aff - Purified
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Buffer
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PBS containing 0.02% Sodium Azide
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Storage
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Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
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Research Area
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Apoptosis/Necrosis, Death Receptors
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Restrictions
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For Research Use only
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Alternatives for antigen "Death Effector Domain Containing 2 (DEDD2)", type "Antibodies"
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Hosts
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Rabbit (29)
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Reactivities
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Human (24), Mouse (Murine) (21), Rat (Rattus) (20), Cow (Bovine) (10), Dog (Canine) (9), Chicken (4), Rabbit (4), Horse (Equine) (3), Pig (Porcine) (2), Sheep (Ovine) (1)
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Applications
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Flow Cytometry (FACS) (16), Immunofluorescence (IF) (15), Western Blotting (WB) (10), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (4), Immunohistochemistry (Frozen Sections) (IHC (fro)) (3), Immunoprecipitation (IP) (3), ELISA (1), Enzyme Immunoassay (EIA) (1), Immunoelectron Microscopy (IEM) (1)
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Conjugates
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Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
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Alternatives 
