anthrax Toxin Receptor 1 (ANTXR1) (C-Term) antibody

Details for Product No. ABIN264594
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Antigen
Epitope
C-Term
(22), (22), (16), (10), (6), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(135), (44), (39), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(119), (18), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (9), (9), (8), (7), (7), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(78), (66), (34), (22), (20), (13), (11), (9), (5), (3), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Immunogen Synthetic peptide corresponding to 13 amino acids near the C-terminal of human ATR
Specificity This antibody reacts to Anthrax Toxin Receptor (ATR, TEM8). Recognizes only the 60 kDa isoform.
Purification Ion exchange chromatography
Alternative Name Anthrax Toxin Receptor 1 (ANTXR1 Antibody Abstract)
Background TEM8 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has also been shown to be a docking protein or receptor for Bacillus anthracistoxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor(EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.Synonyms: ANTXR1, ATR, TEM8, Tumor endothelial marker 8
Gene ID 84168
NCBI Accession NP_060623
UniProt Q9H6X2
Research Area Toxicology, Receptors
Application Notes Western Blot: 1-2g/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1,0 mg/mL
Buffer PBS containing 0.02 % Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Carson-Walter, Watkins, Nanda et al.: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

Cross, Lindsey, Fantes et al.: "The structure of a subterminal repeated sequence present on many human chromosomes." in: Nucleic acids research, Vol. 18, Issue 22, pp. 6649-57, 1991 (PubMed).

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Catalog No. ABIN264594
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