anthrax Toxin Receptor 1 (ANTXR1) antibody

Details for Product No. ABIN264595
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms Tem8, Antrx1, 2310008J16Rik, 2810405N18Rik, ATR, TEM8, ANTXR1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(81), (42), (38), (13), (12), (2)
Host
Rabbit
(76), (8), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(51), (28), (20), (16), (11), (7), (5), (4), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN264595
Quantity 0.1 mg
Price
533.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide corresponding to 13 amino acids near the center of human ATR
Specificity This antibody reacts to Anthrax Toxin receptor (ATR, TEM8). Recognizes all three isoforms (36, 40 and 60kDa).
Purification Ion exchange chromatography
Alternative Name Anthrax toxin receptor 1
Background TEM8 is a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. This protein has also been shown to be a docking protein or receptor for Bacillus anthracistoxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor(EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants have been described.
Alternate names: ANTXR1, ATR, TEM8, Tumor endothelial marker 8
Gene ID 84168
NCBI Accession NP_060623.2
UniProt Q9H6X2
Research Area Toxins, Receptors
Application Notes Immunohistochemistry: 2g/ml. Western blot: 0.5-1.0g/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1,0 mg/mL
Buffer PBS containing 0.02% Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Cross, Lindsey, Fantes et al.: "The structure of a subterminal repeated sequence present on many human chromosomes." in: Nucleic acids research, Vol. 18, Issue 22, pp. 6649-57, 1991 (PubMed).

Carson-Walter, Watkins, Nanda et al.: "Cell surface tumor endothelial markers are conserved in mice and humans." in: Cancer research, Vol. 61, Issue 18, pp. 6649-55, 2001 (PubMed).

Hosts (76), (8), (4)
Reactivities (81), (42), (38), (13), (12), (2)
Applications (51), (28), (20), (16), (11), (7), (5), (4), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Epitopes (16), (8), (4), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
back to top