Epstein-Barr Virus Induced 3 (EBI3) (N-Term) antibody

Details for Product No. ABIN264660
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Antigen
Synonyms IL-27B, IL27B, EBI-3, IL-27
Epitope
N-Term
(13), (6), (6), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(66), (62), (25), (12), (12), (12), (1)
Host
Rabbit
(63), (21), (14), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(13), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(82), (60), (20), (16), (15), (12), (10), (10), (4), (3), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN264660
544.50 $
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Immunogen Synthetic peptide corresponding to 16 amino acids near the amino terminus of human IL-27
Specificity This antibody reacts with the N-terminal of IL-27.
Purification Immunoaffinity chromatography
Alternative Name EBI3 / IL27B
Background IL27 is a recently discovered member of the IL6/IL12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL12 p35-related protein termed p28. IL27 is produced after activation by antigen-presenting cells and induces proliferation of naive but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL27 is involved in the regulation of immune processes.
Alternate names: EBV-induced gene 3 protein, Epstein-Barr virus-induced gene 3 protein, IL-27 subunit beta, IL-27B, Interleukin-27 subunit beta
Gene ID 10148
NCBI Accession NP_005746
UniProt Q14213
Application Notes Western blot: 2 - 4g/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Background publications Pflanz, Timans, Cheung et al.: "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells." in: Immunity, Vol. 16, Issue 6, pp. 779-90, 2002 (PubMed).

Pflanz, Hibbert, Mattson et al.: "WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 4, pp. 2225-31, 2004 (PubMed).

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