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TNF Receptor-Associated Factor 3 (TRAF3) (C-Term) antibody

Details for Product No. ABIN264769
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Antigen
Synonyms CAP-1, CAP1, CD40bp, CRAF1, IIAE5, LAP1, amn, T-BAM, AI528849, LOC100218184
Epitope
C-Term
(11), (9), (3), (2), (2), (1), (1)
Reactivity
Human, Mouse (Murine)
(61), (46), (29), (1)
Host
Rabbit
(57), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(52), (25), (11), (10), (9), (8), (5), (2), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN264769
544.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide corresponding to 16 amino acids near the carboxy terminus of Human TRAF3
Specificity This antibody reacts with TRAF3.
Purification Immunoaffinity chromatography
Alternative Name TRAF3 / CRAF1
Background Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the Interleukin 1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF3, originally named CRAF1, interacts directly with the CD40 cytoplasmic tail through a region of similarity to the tumor necrosis factor-alpha (TNF-alpha) receptor- associated factors. TRAF3 binds only a single site, which contains the sequence PEQET, whereas TRAF1 and TRAF2 are capable of binding to either the PEQET site or an additional downstream domain.
Alternate names: CAP-1, CAP1, CD40 receptor-associated factor 1, CD40-binding protein, CD40BP, LAP1, LMP1-associated protein, TNF receptor-associated factor 3
Gene ID 7187
NCBI Accession NP_001186356.1
UniProt Q13114
Application Notes Western blot: 1 - 2mg/ml. Immunohistochemistry: 2g/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Background publications Arch, Gedrich, Thompson: "Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death." in: Genes & development, Vol. 12, Issue 18, pp. 2821-30, 1998 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN264769
544.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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