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Details for Product No. ABIN264770

Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) antibody

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Antigen
Synonyms APO3L, DR3LG, TWEAK, Apo3l, Dr3l, Dr3lg, Tweak
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN264770
Quantity 0.1 mg
Price
533.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant Human TWEAK.
Specificity This antibody reacts to TWEAK.
Purification DEAE Chromatography
Alternative Name TWEAK / TNFSF12
Background TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. It is widely expressed, has high constitutive expression in heart placenta, lung, muscle, kidney, pancreas, and HUVEC. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TWEAK can induce apoptosis via multiple pathways of cell death in a cell type specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.
Alternate names: APO3 ligand, APO3L, DR3LG, TNF-related weak inducer of apoptosis, Tumor necrosis factor ligand superfamily member 12
Gene ID 8742
NCBI Accession NP_003800.1
UniProt O43508
Application Notes Western blot: 0.5 - 1g/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Chicheportiche, Bourdon, Xu et al.: "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32401-10, 1998 (PubMed).

Wiley, Winkles: "TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor." in: Cytokine & growth factor reviews, Vol. 14, Issue 3-4, pp. 241-9, 2003 (PubMed).

Alternatives for antigen "Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12)", type "Antibodies"
Hosts (37), (16), (15), (11)
Reactivities (62), (33), (8), (2)
Applications (54), (33), (28), (13), (7), (5), (4), (4), (2), (2), (2), (2), (2), (1), (1)
Conjugates (13), (6)
Epitopes (4), (3), (2), (2), (1), (1), (1)
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