Tumor Necrosis Factor (Ligand) Superfamily, Member 12 (TNFSF12) antibody

Details for Product No. ABIN264770
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Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(96), (42), (10), (3)
Host
Rabbit
(59), (21), (21), (16)
Clonality
Polyclonal
Conjugate
Un-conjugated
(14), (9), (2), (2), (2), (2)
Application
Western Blotting (WB)
(81), (48), (36), (21), (10), (9), (7), (6), (6), (2), (2), (2), (1), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Availability Discontinued
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Immunogen Recombinant Human TWEAK.
Specificity This antibody reacts to TWEAK.
Purification DEAE Chromatography
Alternative Name TWEAK / TNFSF12 (TNFSF12 Antibody Abstract)
Background TWEAK is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. It is widely expressed, has high constitutive expression in heart placenta, lung, muscle, kidney, pancreas, and HUVEC. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. TWEAK can induce apoptosis via multiple pathways of cell death in a cell type specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.Synonyms: APO3 ligand, APO3L, DR3LG, TNF-related weak inducer of apoptosis, Tumor necrosis factor ligand superfamily member 12
Gene ID 8742
NCBI Accession NP_003800
UniProt O43508
Application Notes Western blot: 0.5 - 1g/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Wiley, Winkles: "TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor." in: Cytokine & growth factor reviews, Vol. 14, Issue 3-4, pp. 241-9, 2003 (PubMed).

Chicheportiche, Bourdon, Xu et al.: "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32401-10, 1998 (PubMed).

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Catalog No. ABIN264770
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