TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) antibody

Details for Product No. ABIN264778
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Antigen
Synonyms C86182, E430026L09Rik, I-TRAF, ITRAF, TRAF2
Epitope
N-Term
(16), (15), (7), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(79), (35), (35), (2), (2), (2)
Host
Rabbit
(74), (3), (3), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(71), (30), (19), (16), (10), (9), (9), (7), (6), (3), (3)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN264778
500.50 $
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Immunogen Synthetic peptide corresponding to 14 amino acids near the amino terminal of human TANK
Specificity This antibody reacts with the N-terminus of TANK.
Purification Immunoaffinity chromatography
Alternative Name TANK / ITRAF
Background TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF- mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. At least 2 isoforms of TANK are known to exist.
Alternate names: I-TRAF, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, TRAF2
Gene ID 10010
NCBI Accession NP_001186064
UniProt Q92844
Application Notes Western blot: 0.5 - 1g/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Rothe, Xiong, Shu et al.: "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 16, pp. 8241-6, 1996 (PubMed).

Pomerantz, Baltimore: "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase." in: The EMBO journal, Vol. 18, Issue 23, pp. 6694-704, 2000 (PubMed).

Rao, Kadesch: "The intracellular form of notch blocks transforming growth factor beta-mediated growth arrest in Mv1Lu epithelial cells." in: Molecular and cellular biology, Vol. 23, Issue 18, pp. 6694-701, 2003 (PubMed).

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