anti-TNFRSF10B antibody (Tumor Necrosis Factor Receptor Superfamily, Member 10b) (Isoform 1)

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Antigen
Alternatives
Epitope
Isoform 1, N-Term, AA 409-427
(21), (17), (15), (15), (12), (10), (9), (8), (6), (6), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(276), (81), (19), (2), (1), (1)
Host
Rabbit
(183), (116), (18), (9), (8), (2)
Clonality
Polyclonal
Conjugate
This TNFRSF10B antibody is un-conjugated
(26), (24), (12), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB)
(175), (122), (77), (43), (36), (35), (23), (21), (14), (12), (12), (7), (5), (3), (1), (1)
Pubmed 1 reference available
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Quantity 0.1 mg
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Immunogen Synthetic peptide corresponding to a.a. 409-427 (LGERLAKQKIEDHLLSSGK, isoform 1) of human TRICK 2 precursor conjugated to KLH at the N-terminus
Specificity This antibody recognizes amino acids 409 - 427 of TRICK 2 isoform 1. The same sequence is found at amino acids 380-398 in isoform 2.
Purification Immunoaffinity chromatography
Alternative Name CD262 / TRAILR2 (TNFRSF10B Antibody Abstract)
Background DR5 contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.Synonyms: DR5, Death receptor 5, KILLER, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAIL-R2, TRICK2, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9
Gene ID 8795
NCBI Accession NP_003833
UniProt O14763
Research Area Signaling, Apoptosis/Necrosis
Pathways p53 Signaling, Apoptosis
Application Notes Western blot: band of approximately 57 kDa is detected. Positive control: Whole cell lysatefrom HL60, HeLa or Jurkat cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS, pH 7.4
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Background publications Screaton, Mongkolsapaya, Xu et al.: "TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL." in: Current biology : CB, Vol. 7, Issue 9, pp. 693-6, 1998 (PubMed).

Catalog No. ABIN264779
$588.50
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