Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14) (N-Term) antibody

Details for Product No. ABIN264784
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Antigen
Synonyms ATAR, CD270, HVEA, HVEM, LIGHTR, TR2, Atar, HveA, Hvem, Tnfrs14
Epitope
N-Term
(12), (12), (4), (2), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(111), (21), (17)
Host
Rabbit
(74), (30), (6), (5), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(67), (51), (42), (20), (13), (12), (11), (10), (6), (2), (2), (2), (1)
Pubmed 5 references available
Catalog no. ABIN264784
Quantity 0.1 mg
Price
544.50 $   Plus shipping costs $45.00
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days

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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide corresponding to 15 amino acids near the amino terminus of human TNFRSF14
Specificity This antibody reacts with TNFRSF14
Purification Immunoaffinity chromatography
Alternative Name TNFRSF14 / HVEM
Background TNFRSF14, also known as HVEM (herpes virus entry mediator), TR2 (TNF receptor like molecule) and ATAR (another TRAF-associated receptor), is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.
Alternate names: HVEA, Herpesvirus entry mediator A, TR2, Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor-like 2
Gene ID 8764
NCBI Accession NP_003811.2
UniProt Q92956
Application Notes Western blot: 1 - 2mg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Montgomery, Warner, Lum et al.: "Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family." in: Cell, Vol. 87, Issue 3, pp. 427-36, 1996 (PubMed).

Marsters, Ayres, Skubatch et al.: "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1." in: The Journal of biological chemistry, Vol. 272, Issue 22, pp. 14029-32, 1997 (PubMed).

Mauri, Ebner, Montgomery et al.: "LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator." in: Immunity, Vol. 8, Issue 1, pp. 21-30, 1998 (PubMed).

Granger, Rickert: "LIGHT-HVEM signaling and the regulation of T cell-mediated immunity." in: Cytokine & growth factor reviews, Vol. 14, Issue 3-4, pp. 289-96, 2003 (PubMed).

Watts: "TNF/TNFR family members in costimulation of T cell responses." in: Annual review of immunology, Vol. 23, pp. 23-68, 2005 (PubMed).

Hosts (74), (30), (6), (5), (4)
Reactivities (111), (21), (17)
Applications (67), (51), (42), (20), (13), (12), (11), (10), (6), (2), (2), (2), (1)
Conjugates (8), (5), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (12), (4), (2), (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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