Ectodysplasin A2 Receptor (EDA2R) antibody

Details for Product No. ABIN264808
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Antigen
Synonyms EDA-A2R, EDAA2R, TNFRSF27, XEDAR, 9430060M22Rik, Xedar, RGD1564025
Reactivity
Human
(61), (13), (11)
Host
Rabbit
(46), (15)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(45), (28), (9), (9), (8), (3), (3), (2), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN264808
544.50 $
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Immunogen Recombinant human XEDAR
Specificity This antibody reacts to XEDAR.
Purification Immunoaffinity chromatography
Alternative Name EDA2R / TNFRSF27
Background EDA2R is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappaB and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 have been found to block apoptosis following EDA-A2 treatment.Synonyms: EDA-A2 receptor, Tumor necrosis factor receptor superfamily member 27, UNQ2448/PRO5727/PRO34080, X-linked ectodysplasin-A2 receptor, XEDAR
Gene ID 60401
NCBI Accession NP_001186616
UniProt Q9HAV5
Application Notes Western blot: 0.5 - 1g/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.
Background publications Yan, Wang, Hymowitz et al.: "Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors." in: Science (New York, N.Y.), Vol. 290, Issue 5491, pp. 523-7, 2000 (PubMed).

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