Ectodysplasin A2 Receptor (EDA2R) antibody

Details for Product No. ABIN264808
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Synonyms XEDAR, EDAA2R, EDA-A2R, TNFRSF27, 9430060M22Rik, Xedar, RGD1564025
(43), (13), (11)
(38), (6)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(34), (13), (10), (9), (7), (3), (3), (1)
Pubmed 1 reference available
Catalog no. ABIN264808
Quantity 0.1 mg
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Immunogen Recombinant human XEDAR
Specificity This antibody reacts to XEDAR.
Purification Immunoaffinity chromatography
Alternative Name EDA2R / TNFRSF27
Background EDA2R is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappaB and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 have been found to block apoptosis following EDA-A2 treatment.
Alternate names: EDA-A2 receptor, Tumor necrosis factor receptor superfamily member 27, UNQ2448/PRO5727/PRO34080, X-linked ectodysplasin-A2 receptor, XEDAR
Gene ID 60401
NCBI Accession NP_001186616.1
UniProt Q9HAV5
Application Notes Western blot: 0.5 - 1g/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.02% Sodium Azide
Preservative Sodium azide
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Yan, Wang, Hymowitz et al.: "Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors." in: Science (New York, N.Y.), Vol. 290, Issue 5491, pp. 523-7, 2000 (PubMed).

Hosts (38), (6)
Reactivities (43), (13), (11)
Applications (34), (13), (10), (9), (7), (3), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (2), (2), (1)
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