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Superoxide Dismutase 1, Soluble (SOD1) antibody
| Antigen | Superoxide Dismutase 1, Soluble (SOD1) |
| Synonyms |
ALS, SOD, ALS1, IPOA, homodimer, Cu, Zn Sod, Zn-SOD, Cu-Zn SOD, Cu/Zn SOD, Cu/Zn superoxide dismutase, Cu/ZnSOD, CuSOD, CuZn SOD, CuZn-SOD, CuZnSOD, Cu[2+]/Zn[2+]SOD, G, SOD-1, SOD1, To, To-1, cSOD, l ...
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| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Cow (Bovine) |
| Application |
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Immunoprecipitation (IP), Western Blotting (WB)
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| Catalog no. | ABIN264857 |
| Quantity | 25 µl (1.0 mg/ml) (Variants) |
| Price | 215.00 $ Plus shipping costs $35.00 |
| Shipping to |
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| Availability | Ships within 7 to 10 Business Days |
Additional Information
| Characteristics | Synonyms: SOD-1, CuZn-SOD, CuZnSOD, IPOA, ALS1, Superoxide dismutase [Cu-Zn] |
| Alternative name | Superoxide Dismutase 1 (SOD1) |
| Swiss-Prot | P00441 |
| Immunogen | Human Cu/Zn SOD |
| Cross-Reactivity | Cow (Bovine), Dog (Canine), Hamster, Human, Monkey, Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus), Sheep (Ovine), Xenopus laevis, Coral |
| Isotype | IgG (Matching secondary antibodies) |
| Description | Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present inalmost every cell in the body (3). It works by catalyzing the dismutation of the superoxideradical O2¯ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase andglutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defensemechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Znions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each arelinked by two cysteines forming an intra-subunit disulphide bridge (3). The second form(SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is ahomotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it containsCu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDAand it exists only in the extracellular space(9). SOD3 can also be distinguished by itsheparin-binding capacity (1). |
| Specificity | Detects 23kDa (human) and 19kDa (other species) proteins, corresponding to themolecular mass of Cu/Zn superoxide dismutase (SOD) on SDS-PAGE immunoblots. Species: Human, Rat, Mouse, Bovine, Monkey, Coral, Dog, Hamster, Pig, Rabbit, Sheep,Xenopus. Others not tested. |
| Synonyms | ALS, SOD, ALS1, IPOA, homodimer, Cu, Zn Sod, Zn-SOD, Cu-Zn SOD, Cu/Zn SOD, Cu/Zn superoxide dismutase, Cu/ZnSOD, CuSOD, CuZn SOD, CuZn-SOD, CuZnSOD, Cu[2+]/Zn[2+]SOD, G, SOD-1, SOD1, To, To-1, cSOD, l(3)108, l(3)68Af', l(3)G, DmelCG11793, CG11793, LOC692639, CU/ZN-SOD, sod1, SODC, DKFZP469M1833 |
Application Details
| Application Notes | Western blot (6,8): 0.2 ug/ml was sufficient for detection of Cu/Zn SOD in 20 g of HeLacell lysate. Immunoprecipitation (8). EIA (6). Immunohistochemistry on frozen sections(7). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. |
| Concentration | 1.0 mg/ml |
| Purification | Aff - Purified |
| Buffer | PBS (pH7.0), 0.09 % NaN3, 50 % glycerol |
| Storage | Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing. Shelf life: one year from despatch. |
| Research Area | Inflammation, Enzymes, Metabolism |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Superoxide Dismutase 1, Soluble (SOD1)", type "Antibodies"
