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AKT2 antibody

AKT2 Reactivity: Human, Mouse, Rat, Dog, Chicken, Monkey, Cow, Pig, Guinea Pig, Hamster, Rabbit, Sheep, Xenopus laevis WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN264873
  • Target See all AKT2 Antibodies
    AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))
    Reactivity
    • 187
    • 103
    • 68
    • 16
    • 15
    • 13
    • 13
    • 13
    • 11
    • 10
    • 10
    • 10
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    Human, Mouse, Rat, Dog, Chicken, Monkey, Cow, Pig, Guinea Pig, Hamster, Rabbit, Sheep, Xenopus laevis
    Host
    • 166
    • 28
    • 5
    • 2
    • 1
    • 1
    Rabbit
    Clonality
    • 167
    • 34
    Polyclonal
    Conjugate
    • 97
    • 17
    • 16
    • 11
    • 9
    • 9
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This AKT2 antibody is un-conjugated
    Application
    • 171
    • 109
    • 73
    • 38
    • 28
    • 27
    • 26
    • 20
    • 19
    • 10
    • 8
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Specificity
    This antibody detects a ~65 kDa protein, corresponding to the Molecular Mass of Akt2 PKB beta on SDS-PAGE immunoblots. Does not react with PKB-alpha (Akt1) or PKB-gamma (Akt3).
    Purification
    Affinity Chromatography
    Immunogen
    A five residue synthetic peptide based on the Human Akt2, coupled to KLH
    Isotype
    IgG
    Top Product
    Discover our top product AKT2 Primary Antibody
  • Application Notes
    Western blot (3): 1: 13000 dilution of SPC-148 was ufficient for detection of PKBβ in 20 μg ofHeLa cell lysate by ECL immunoblot analysis. ELISA.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    TBS, 0.09 % Sodium Azide, 50 % Glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    AKT2 (V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2))
    Alternative Name
    AKT2 / PKB beta (AKT2 Products)
    Synonyms
    AKT2 antibody, pkbb antibody, pkbbeta antibody, pkbss antibody, prkbb antibody, rac-beta antibody, v-akt2 antibody, 2410016A19Rik antibody, AW554154 antibody, PKB antibody, PKBbeta antibody, HIHGHH antibody, PKBB antibody, PKBBETA antibody, PRKBB antibody, RAC-BETA antibody, cb945 antibody, akt2-a antibody, AKT serine/threonine kinase 2 antibody, v-akt murine thymoma viral oncogene homolog 2 antibody, thymoma viral proto-oncogene 2 antibody, v-akt murine thymoma viral oncogene homolog 2 L homeolog antibody, AKT2 antibody, akt2 antibody, Akt2 antibody, akt2.L antibody
    Background
    Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises three highly homologous members known as PKB alpha (Akt1), PKB beta (Akt2) and PKB gamma (Akt3). PKB/Akt is a growth-factor-regulated protein kinase which contains a Pleckstrin Homology (PH) domain which might be important for dimerization of the kinase. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1) and PDK2 (1-3). Myelin basic protein and histone H2B are in vitro substrates for PKB, while glycogen synthase kinase-3 has been implicated as a physiological target (4). Key roles for this enzyme can be found in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration (1-3).Synonyms: Protein kinase Akt-2, Protein kinase B beta, RAC-PK-beta, RAC-beta serine/threonine-protein kinase
    Gene ID
    208
    NCBI Accession
    NP_001617
    UniProt
    P31751
    Pathways
    PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, TLR Signaling, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Hepatitis C, VEGF Signaling
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