Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (N-Term), (AA 994-1009) antibody

Details for Product No. ABIN264987
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Antigen
Synonyms
acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, ik:tdsubc_2g5, si:zc14a17.12, wu:fb04g06, wu:fb40f03, wu:fb68h03, wu:fb80f07, wu:fc12e10, xx:tdsubc_2g5, acn, ACINUS, ACN, fSAP152,  ... show more
acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, ik:tdsubc_2g5, si:zc14a17.12, wu:fb04g06, wu:fb40f03, wu:fb68h03, wu:fb80f07, wu:fc12e10, xx:tdsubc_2g5, acn, ACINUS, ACN, fSAP152, 2610036I19Rik, 2610510L13Rik, Acinus, Acn, C79325, acinusL, acinusS, mKIAA0670 show less
Epitope
N-Term, AA 994-1009
(41), (20), (12), (8), (7), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(135), (41), (26), (24), (24), (12), (1)
Host
Rabbit
(135), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(117), (41), (28), (20), (15), (14), (7), (6), (4), (2), (2), (1)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN264987
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Immunogen Synthetic peptide (DDPVRTAQVPSPPRGK) corresponding to amino acids 994 to 1009 of human AcinusL, 267 to 282 of human AcinusS’, or 236 to 251 of human AcinusS, which are identical to those of mouse Acinus (2). The selected antigenic sequence is located near the N-terminus of active peptide p17.
Isotype IgG
Specificity This antibody reacts to Acinus / ACIN1.
Purification Purified
Alternative Name Acinus / ACIN1
Background Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE (1). A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS' (2).Synonyms: Apoptotic chromatin condensation inducer in the nucleus, KIAA0670
Gene ID 22985
NCBI Accession NP_001158286
UniProt Q9UKV3
Research Area Cell Cycle, Apoptosis/Necrosis
Application Notes Western Blot: 0.5 to 1.0 μg/mL. Detects a 220 kDa band in K562 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline solution containing 0.02 % sodium azide as a preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment The antibody can be shipped at ambient temperature. Store (in aliquots) at 2-8 °C.
Supplier Images
anti-Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (N-Term), (AA 994-1009) antibody anti-Apoptotic Chromatin Condensation Inducer 1 (ACIN1) (N-Term), (AA 994-1009) antibody
Background publications Zamzami, Kroemer: "Condensed matter in cell death." in: Nature, Vol. 401, Issue 6749, pp. 127-8, 1999 (PubMed).

Sahara, Aoto, Eguchi et al.: "Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation." in: Nature, Vol. 401, Issue 6749, pp. 168-73, 1999 (PubMed).

Validation Images
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