You are viewing an incomplete version of our website. Please click to reload the website as full version.

Neurturin antibody (NRTN) (AA 178-193)

Details for Product anti-NRTN Antibody No. ABIN264999, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Synonyms NRTN, NTN
AA 178-193
(30), (14), (13), (13), (11), (5), (2), (2)
(97), (38), (20), (2), (2), (2)
(72), (31), (4), (3)
This Neurturin antibody is un-conjugated
(9), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(89), (56), (14), (11), (9), (7), (4), (2), (1), (1)
Pubmed 7 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide corresponding to amino acids 178 to 193 of human neuturin.
Isotype IgG
Specificity This antibody reacts to Neurturin (NTN).
Purification Purified
Alternative Name Neurturin (NRTN Antibody Abstract)
Background Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin1,2. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRa3,4. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently3-8 and termed GDNFRb, Ret ligand 2 (RETL2) or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently (9). NTN binds to and forms a complex with GFRa-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.Synonyms: NRTN
Gene ID 4902
NCBI Accession NP_004549
UniProt Q99748
Research Area Neurology
Application Notes Western Blot: 1 μg/mL. Detects a 14 kDa band in HeLa cell lysates containing full lengthrecombinant neuturin.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline solution containing 0.02 % sodium azide as a preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
Supplier Images
 image for anti-Neurturin antibody (NRTN) (AA 178-193) (ABIN264999) anti-Neurturin (NRTN) (AA 178-193) antibody
Background publications Heuckeroth, Kotzbauer, Copeland et al.: "Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3." in: Genomics, Vol. 44, Issue 1, pp. 137-40, 1997 (PubMed).

Suvanto, Wartiovaara, Lindahl et al.: "Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha." in: Human molecular genetics, Vol. 6, Issue 8, pp. 1267-73, 1997 (PubMed).

Buj-Bello, Adu, Piñón et al.: "Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase." in: Nature, Vol. 387, Issue 6634, pp. 721-4, 1997 (PubMed).

Klein, Sherman, Ho et al.: "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor." in: Nature, Vol. 387, Issue 6634, pp. 717-21, 1997 (PubMed).

Baloh, Tansey, Golden et al.: "TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret." in: Neuron, Vol. 18, Issue 5, pp. 793-802, 1997 (PubMed).

Sanicola, Hession, Worley et al.: "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 12, pp. 6238-43, 1997 (PubMed).

Kotzbauer, Lampe, Heuckeroth et al.: "Neurturin, a relative of glial-cell-line-derived neurotrophic factor." in: Nature, Vol. 384, Issue 6608, pp. 467-70, 1997 (PubMed).

Catalog No. ABIN264999
Plus shipping costs $45.00

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)