Neurturin (NRTN) (AA 178-193) antibody

Details for Product No. ABIN264999
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Antigen
Synonyms NTN, NRTN
Epitope
AA 178-193
(8), (4), (1)
Reactivity
Human
(55), (20), (14), (12), (12)
Host
Rabbit
(44), (9), (4), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(47), (35), (11), (10), (6), (2), (2), (2), (2), (1), (1)
Pubmed 7 references available
Catalog no. ABIN264999
Quantity 0.1 mg
Price
368.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide corresponding to amino acids 178 to 193 of human neuturin.
Isotype IgG
Specificity This antibody reacts to Neurturin (NTN).
Purification Purified
Alternative Name Neurturin
Background Glial cell line-derived neurotrophic factor (GDNF) plays key roles in the control of vertebrate neuron survival and differentiation. A novel neurotrophic factor was recently cloned from human and mouse and designated neurturin1,2. Physiological responses to neurturin (NTN) require the presence of receptor tyrosine kinase RET and a novel glycosylphosphatidylinositol linked receptor NTNRa3,4. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently3-8 and termed GDNFRb, Ret ligand 2 (RETL2) or TGF-b-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa-2 recently (9). NTN binds to and forms a complex with GFRa-2 and the Ret PTK and activates the RET receptor tyrosine kinase pathway. Both NTN and GDNF can activate the MAP kinase and phosphatidylinositol 3-kinase pathways and play a critical role in the development of many neuronal populations. Neurturin and GDNF define a new family of neurotrophic factors.
Alternate names: NRTN
Gene ID 4902
NCBI Accession NP_004549.1
UniProt Q99748
Research Area Neurology
Application Notes Western Blot: 1 ug/ml. Detects a 14 kDa band in HeLa cell lysates containing full lengthrecombinant neuturin. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer Phosphate buffered saline solution containing 0.02% sodium azide as a preservative
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
Expiry Date 12 months
Supplier Images
anti-Neurturin (NRTN) (AA 178-193) antibody anti-Neurturin (NRTN) (AA 178-193) antibody
Background publications Kotzbauer, Lampe, Heuckeroth et al.: "Neurturin, a relative of glial-cell-line-derived neurotrophic factor." in: Nature, Vol. 384, Issue 6608, pp. 467-70, 1997 (PubMed).

Sanicola, Hession, Worley et al.: "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 12, pp. 6238-43, 1997 (PubMed).

Baloh, Tansey, Golden et al.: "TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret." in: Neuron, Vol. 18, Issue 5, pp. 793-802, 1997 (PubMed).

Klein, Sherman, Ho et al.: "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor." in: Nature, Vol. 387, Issue 6634, pp. 717-21, 1997 (PubMed).

Buj-Bello, Adu, Piñón et al.: "Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase." in: Nature, Vol. 387, Issue 6634, pp. 721-4, 1997 (PubMed).

Suvanto, Wartiovaara, Lindahl et al.: "Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha." in: Human molecular genetics, Vol. 6, Issue 8, pp. 1267-73, 1997 (PubMed).

Heuckeroth, Kotzbauer, Copeland et al.: "Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3." in: Genomics, Vol. 44, Issue 1, pp. 137-40, 1997 (PubMed).

Hosts (44), (9), (4), (2)
Reactivities (55), (20), (14), (12), (12)
Applications (47), (35), (11), (10), (6), (2), (2), (2), (2), (1), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (4), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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