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Visual System Homeobox 2 (VSX2) (AA 264-361), (C-Term) antibody

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Synonyms VSX2, CHX10, c-ret, cret, etID315074.13, ret1, wu:fd13h01, HOX10, MCOP2, MCOPCB3, RET1, Chx10, Hox-10, Hox10, or, Vsx-2, alx, chx10
C-Term, AA 264-361
(25), (16), (12), (7), (3), (2), (1), (1), (1), (1), (1)
Mouse (Murine), Rat (Rattus)
(38), (15), (12), (9), (3), (1)
(55), (8), (1)
(8), (5), (2), (2), (2), (2), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(48), (33), (4), (4), (4), (3), (2), (2), (1)
Pubmed 7 references available
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Quantity 0.25 mg
Shipping to United States ( )
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Immunogen Antibody raised against a recombinant protein corresponding to amino acids 264 to 361 derived from the C terminal of the human Chx10 protein conjugated to GST.
Isotype IgG
Specificity This antibody recognizes chx 10 (C-Term). Other species not tested.
Purification Purified
Alternative Name VSX2 / CHX10 (VSX2 Antibody Abstract)
Background Chx10 is a 46 kDa homeodomain protein of the paired-like class that is essential for development of the mammalian eye. Mutations in Chx10 cause microphthalmia, a cause of congenital blindness in humans, and the ocular retardation (or) phenotype in mice. In the developing mouse retina Chx10 is expressed in retinal progenitors, while in the mature retina, Chx10 expression becomes restricted to bipolar neurons. Concurrent with these expression patterns, the Chx10-/- (or) retina is thin due to a defect in proliferation of retinal progenitors, and lacks bipolar neurons. Chx10 is also expressed in the developing brainstem, thalamus, and spinal cord.Synonyms: Ceh-10 homeodomain-containing homolog, HOX10, Homeobox protein CHX10, Visual system homeobox 2
Molecular Weight 46 kDa
Gene ID 12677
NCBI Accession NP_031727
UniProt Q61412
Application Notes Western Blot: 0.5-1.0 mg/mL. Detects a 46 kDa band in mouse and rat retinal tissue lysates. Immunohistochemistry on Frozen Sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS containing 0.08 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Can be shipped at ambient temperature.
Supplier Images
Image no. 1 for anti-Visual System Homeobox 2 (VSX2) (AA 264-361), (C-Term) antibody (ABIN265010) anti-Visual System Homeobox 2 (VSX2) (AA 264-361), (C-Term) antibody
Product cited in: Francius, Harris, Rucchin et al.: "Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord." in: PLoS ONE, Vol. 8, Issue 8, pp. e70325, 2013 (PubMed).

Nittner, Lambertz, Clermont et al.: "Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation." in: Nature cell biology, Vol. 14, Issue 9, pp. 958-65, 2012 (PubMed).

Elshatory, Everhart, Deng et al.: "Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 46, pp. 12707-20, 2007 (PubMed).

Osakada, Ooto, Akagi et al.: "Wnt signaling promotes regeneration in the retina of adult mammals." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 15, pp. 4210-9, 2007 (PubMed).

Background publications Ferda Percin, Ploder, Yu et al.: "Human microphthalmia associated with mutations in the retinal homeobox gene CHX10." in: Nature genetics, Vol. 25, Issue 4, pp. 397-401, 2000 (PubMed).

Chen, Cepko: "Expression of Chx10 and Chx10-1 in the developing chicken retina." in: Mechanisms of development, Vol. 90, Issue 2, pp. 293-7, 2000 (PubMed).

Liu, Chen, Ploder et al.: "Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer." in: Neuron, Vol. 13, Issue 2, pp. 377-93, 1994 (PubMed).

Catalog No. ABIN265010
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