SLA antibody

Catalog No. ABIN265047

Product Details anti-SLA Antibody

Target: SLA (Src-Like-Adaptor (SLA))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLA antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to SLA.

Purification: Purified

Immunogen: Synthetic peptide derived from the human SLAP1 protein.

Isotype: IgG

Application Details

Application Notes: Western Blot: 5 - 10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Target Details for SLA

Target: SLA (Src-Like-Adaptor (SLA))

Alternative Name: SLA (SLA Products)

Synonyms: SLA1 antibody, SLAP antibody, src-like-adapter antibody, SLA antibody, Slap1 antibody, Slap antibody, Slap-1 antibody, Src like adaptor antibody, Src-like-adaptor antibody, src-like adaptor antibody, SLA antibody, Sla antibody

Background: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. Interacts with EPHA2, VAV1, LCP2 and PDGFRB. The C-terminal domain is essential for the homodimerization and the interaction with CBL. While the interaction with CBL is apparently mediated via the hydrophobic region of this domain, the highly charged region is apparently required for the homodimerization. Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas.Synonyms: SLAP, SLAP-1, SLAP1, Src-like-adapter, Src-like-adapter protein 1

Gene ID: 6503

NCBI Accession: NP_001039021

UniProt: Q13239