GPR19 antibody

Catalog No. ABIN4620341

Product Details anti-GPR19 Antibody

Target: GPR19 (G Protein-Coupled Receptor 19 (GPR19))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR19 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to G Protein-Coupled Receptor GPR4.

Purification: Affinity Purified

Immunogen: Synthetic peptide derived from the GPR4 protein.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1: 400, Tissue lysate should be used at 10 - 50 g/lane.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Ship on dry ice. Store (in aliquots) at -20 °C only.

Target Details for GPR19

Target: GPR19 (G Protein-Coupled Receptor 19 (GPR19))

Abstract: GPR19 Products

Synonyms: zgc:63912 antibody, G protein-coupled receptor 19 antibody, GPR19 antibody, Gpr19 antibody, gpr19 antibody

Background: Sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC) are bioactive lipid molecules involved in numerous biologicals processes. GPR4 shares sequence homology with OGR1 (51 % ), the highest of all GPCR's. GPR4 has been identified as another high affinity receptor for SPC and low affinity receptor for LPC. SPC and LPC stimulate kinase activation and DNA synthesis stimulated, both of which are pertussis toxin-sensitive, suggesting Gi-heterotrimeric G protein involvement. The GPR4 subfamily of GPCR's consists of four receptors that share significant sequence homology, OGR1, TDAG8 and G2A. G2A has been shown to be a potent transforming oncogene. GPR4 also malignantly transforms NIH3T3 cells and TDAG8 malignantly transforms the normal mammary epithelial cell line NMuMG. Overexpression of GPR4 or TDGA8 in HEK293 cells leads to transcriptional activation independent of exogenously added ligand. TDAG8 and GPR4 are also overexpressed in a range of human cancer tissues suggestive of a driving role in maintaining tumor formation.Synonyms: G-protein coupled receptor 19, G-protein coupled receptor 4

Gene ID: 2828

NCBI Accession: NP_005273

UniProt: P46093