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Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) (pThr305) antibody

Details for Product No. ABIN265087
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Antigen
Synonyms CAMKA, PKCCD, PK2CDD, zgc:112538, zgc:123320, camk2, camk2b
Epitope
pThr305
(22), (20), (7), (5), (5), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Chicken, Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
(75), (65), (44), (8), (6), (6), (5), (5), (5), (4), (3), (2), (2), (1), (1), (1), (1)
Host
Rabbit
(74), (45), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Dot Blot (DB), Western Blotting (WB)
(120), (64), (38), (34), (26), (24), (23), (6), (4), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 1 vial
Quantity Comment 10 blots
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Catalog No. ABIN265087
467.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated-Thr305 found in rat brain CaM Kinase II.
Isotype Cocktail
Specificity This antibody reacts to CAMK2A / CaMK II alpha (pThr 305). Antibody detects only phosphorylated protein and does not detect non-phosphorylated protein as shown by the lack of ability of a non-phospho peptide to block the antibody activity.
Purification Affinity Purified
Alternative Name CAMK2A
Background Calcium/calmodulin kinase II (CaM Kinase II) is a multi-functional calcium and calmodulin- dependent protein kinase that mediates cellular responses to second messengers. The antibody was raised against a synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated-Thr305 found in rat brain CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM kinase II with the PSD and reduce LTP and learning.
Alternate names: CAMKA, CaM kinase II subunit alpha, CaM-kinase II alpha chain, CaMK-II subunit alpha, Calcium/calmodulin-dependent protein kinase type II alpha chain, KIAA0968
Gene ID 25400
NCBI Accession NP_037052.1
UniProt P11275
Research Area Kinases/Phosphatases
Application Notes Western Blot: 1: 1000 dilution to provide for 10 miniblots. Dot Blot: 1: 1000 dilution to provide for 10 miniblots. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Ship on gel ice. Store (in aliquots) at -20°C to -70°C.
Expiry Date 12 months
Supplier Images
anti-Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) (pThr305) antibody anti-Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) (pThr305) antibody
Background publications Elgersma, Fedorov, Ikonen et al.: "Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning." in: Neuron, Vol. 36, Issue 3, pp. 493-505, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN265087
467.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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