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CAMK2A antibody (Calcium/calmodulin-Dependent Protein Kinase II alpha) (pThr305)

Details for Product anti-CAMK2A Antibody No. ABIN265087, Supplier: Log in to see
Antigen
  • camk2
  • camk2b
  • CAMKA
  • CaMKII
  • mKIAA0968
  • PK2CDD
  • PKCCD
  • R74975
  • zgc:112538
  • zgc:123320
Alternatives
anti-Human CAMK2A antibody for Western Blotting
Epitope
pThr305
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2
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Reactivity
Cow (Bovine), Chicken, Human, Mouse (Murine), Rat (Rattus), Xenopus laevis
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66
9
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Host
Rabbit
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Clonality
Polyclonal
Conjugate
This CAMK2A antibody is un-conjugated
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Application
Dot Blot (DB), Western Blotting (WB)
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9
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Supplier
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Immunogen Synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated-Thr305 found in rat brain CaM Kinase II.
Isotype Cocktail
Specificity This antibody reacts to CAMK2A / CaMK II alpha (pThr 305). Antibody detects only phosphorylated protein and does not detect non-phosphorylated protein as shown by the lack of ability of a non-phospho peptide to block the antibody activity.
Purification Affinity Purified
Alternative Name CAMK2A (CAMK2A Antibody Abstract)
Background Calcium/calmodulin kinase II (CaM Kinase II) is a multi-functional calcium and calmodulin-dependent protein kinase that mediates cellular responses to second messengers. The antibody was raised against a synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated-Thr305 found in rat brain CaM Kinase II. Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM kinase II with the PSD and reduce LTP and learning.Synonyms: CAMKA, CaM kinase II subunit alpha, CaM-kinase II alpha chain, CaMK-II subunit alpha, Calcium/calmodulin-dependent protein kinase type II alpha chain, KIAA0968
Gene ID 25400
NCBI Accession NP_037052
UniProt P11275
Research Area Kinases/Phosphatases
Pathways WNT Signaling, Interferon-gamma Pathway
Application Notes Western Blot: 1: 1000 dilution to provide for 10 miniblots. Dot Blot: 1: 1000 dilution to provide for 10 miniblots.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Ship on gel ice. Store (in aliquots) at -20 °C to -70 °C.
Supplier Images
 image for anti-CAMK2A antibody (Calcium/calmodulin-Dependent Protein Kinase II alpha) (pThr305) (ABIN265087) anti-Calcium/calmodulin-Dependent Protein Kinase II alpha (CAMK2A) (pThr305) antibody
Background publications Elgersma, Fedorov, Ikonen, Choi, Elgersma, Carvalho, Giese, Silva: "Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning." in: Neuron, Vol. 36, Issue 3, pp. 493-505, 2002