CAMP Responsive Element Binding Protein 1 (CREB1) (pSer133) antibody

Details for Product No. ABIN265094
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Antigen
Synonyms creb, CREB1, Creb1, CREB, 2310001E10Rik, 3526402H21Rik, AV083133, Creb, Creb-1, creb1, zgc:55598
Epitope
pSer133
(75), (35), (27), (20), (19), (15), (15), (8), (8), (5), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(361), (241), (228), (75), (69), (68), (45), (9), (6), (6), (5), (1), (1), (1), (1)
Host
Rabbit
(321), (54), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (9), (9), (7), (6), (6), (6), (6), (6), (6), (6), (2), (2), (2)
Application
Dot Blot (DB), Western Blotting (WB)
(282), (149), (147), (69), (60), (44), (30), (28), (13), (4), (2), (2), (2), (1), (1), (1)
Pubmed 6 references available
Quantity 1 vial
Quantity Comment 10 blots
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Catalog No. ABIN265094
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Immunogen Synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated Ser133 of CREB.
Isotype IgG
Specificity This antibody reacts to CREB (pSer133).
Purification Immunoaffinity Chromatography.
Alternative Name CREB1
Background It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus. The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulusinduced transcription factors. This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory. A variety of protein kinases including protein kinase A (PKA), mitogenactivated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser133), and phosphorylation of Ser133 is required for CREB mediated transcription.
Alternate names: CREB-1, Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element- binding protein 1
Gene ID 1385
NCBI Accession NP_004370
UniProt P16220
Application Notes Suitable for use in Western Blot and Dot Blot (1/1000). Positive Control/Tissue Expression: Rat brain lysates. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer HEPES (pH 7.5) solution containing 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20°C to -70°C.
Expiry Date 12 months
Supplier Images
anti-CAMP Responsive Element Binding Protein 1 (CREB1) (pSer133) antibody anti-CAMP Responsive Element Binding Protein 1 (CREB1) (pSer133) antibody
Background publications Bird: "The essentials of DNA methylation." in: Cell, Vol. 70, Issue 1, pp. 5-8, 1992 (PubMed).

Montminy: "Transcriptional regulation by cyclic AMP." in: Annual review of biochemistry, Vol. 66, pp. 807-22, 1997 (PubMed).

Silva, Kogan, Frankland et al.: "CREB and memory." in: Annual review of neuroscience, Vol. 21, pp. 127-48, 1998 (PubMed).

Abel, Kandel: "Positive and negative regulatory mechanisms that mediate long-term memory storage." in: Brain research. Brain research reviews, Vol. 26, Issue 2-3, pp. 360-78, 1998 (PubMed).

Shaywitz, Greenberg: "CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals." in: Annual review of biochemistry, Vol. 68, Issue 2, pp. 821-61, 2000 (PubMed).

Johannessen, Delghandi, Moens: "What turns CREB on?" in: Cellular signalling, Vol. 16, Issue 11, pp. 1211-27, 2004 (PubMed).

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