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MTA2 antibody (Metastasis Associated 1 Family, Member 2) (AA 652-668)

Details for Product anti-MTA2 Antibody No. ABIN265128, Supplier: Login to see New
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Synonyms pid, mta1l1, MTA2, DKFZp470E0911, MTA1L1, PID, fd61b05, wu:fd61b05, wu:fi29g02, zgc:63487, AW550797, Mata1l1, Mta1l1, mmta2
AA 652-668
(13), (6), (5), (4), (4), (2), (2), (2), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(87), (49), (44), (12), (8), (7), (3), (2), (2), (1)
(83), (5), (2)
This MTA2 antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(75), (18), (16), (15), (11), (8), (4), (3), (3), (2), (1), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Rabbit polyclonal PID antibody was raised against a synthetic peptide corresponding to amino acids 652 to 668 of human PID/MTA2 (6), which differ from the mouse sequence by one amino acid (7).
Isotype IgG
Specificity This antibody reacts to MTA2 / PID. No cross response to MTA1.
Purification Purified
Alternative Name MTA2 (MTA2 Antibody Abstract)
Background The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 pathway, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The transcriptional activity of p53 is modulated by protein stability and acetylation. PID/MTA2, also termed MTA1-L1, was found to be a subunit of nucleosome remodeling and deacetylating (NRD/NuRD) complex (6 - 8). PID/MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by PID/MTA2 represses p53-dependent transcriptional activation and modulates p53-mediated cell growth arrest and apoptosis (6). PID/MTA2 is ubiquitously expressed in human tissues (8).Synonyms: MTA1-L1, MTA1L1, Metastasis-associated 1-like 1, Metastasis-associated protein MTA2, PID, p53 target protein in deacetylase complex
Gene ID 9219
NCBI Accession NP_004730
UniProt O94776
Research Area Chromatin and Nuclear Signaling
Application Notes Western Blot: 0.5 to 1 μg/mL, a 75 kDa band can be detected. Tissue Expression: Widely expressed, located in the nucleus. Positive Control: HeLa cell lysate. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline with 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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 image for anti-MTA2 antibody (Metastasis Associated 1 Family, Member 2) (AA 652-668) (ABIN265128) anti-Metastasis Associated 1 Family, Member 2 (MTA2) (AA 652-668) antibody
Background publications Oda, Arakawa, Tanaka et al.: "p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53." in: Cell, Vol. 102, Issue 6, pp. 849-62, 2000 (PubMed).

Oda, Ohki, Murasawa et al.: "Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis." in: Science (New York, N.Y.), Vol. 288, Issue 5468, pp. 1053-8, 2000 (PubMed).

Tanaka, Arakawa, Yamaguchi et al.: "A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage." in: Nature, Vol. 404, Issue 6773, pp. 42-9, 2000 (PubMed).

Matsuoka, Huang, Elledge: "Linkage of ATM to cell cycle regulation by the Chk2 protein kinase." in: Science (New York, N.Y.), Vol. 282, Issue 5395, pp. 1893-7, 1998 (PubMed).

Catalog No. ABIN265128
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