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TLR3 antibody (N-Term)

TLR3 Reactivity: Human, Mouse WB, IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN265140
  • Target See all TLR3 Antibodies
    TLR3 (Toll-Like Receptor 3 (TLR3))
    Binding Specificity
    • 16
    • 10
    • 9
    • 8
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 99
    • 66
    • 31
    • 6
    • 2
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 86
    • 31
    • 3
    • 2
    Rabbit
    Clonality
    • 89
    • 33
    Polyclonal
    Conjugate
    • 54
    • 18
    • 15
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TLR3 antibody is un-conjugated
    Application
    • 85
    • 43
    • 38
    • 35
    • 24
    • 18
    • 15
    • 15
    • 13
    • 13
    • 8
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Purification
    Purified
    Immunogen
    Peptide corresponding to 15 amino acids near the amino terminus of human TLR3
    Isotype
    IgG
    Top Product
    Discover our top product TLR3 Primary Antibody
  • Application Notes
    Western Blot: 1 to 2 μg/mL: K562 cell lysate can be used as a positive control. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate buffered saline with 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
  • Target
    TLR3 (Toll-Like Receptor 3 (TLR3))
    Alternative Name
    CD283 / TLR3 (TLR3 Products)
    Synonyms
    CD283 antibody, IIAE2 antibody, AI957183 antibody, zgc:123006 antibody, toll like receptor 3 antibody, toll-like receptor 3 antibody, TLR3 antibody, Tlr3 antibody, tlr3 antibody
    Background
    Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection (4). Recently it has been shown to recognize viruses such as Influenza A (5) and West Nile Virus and can mediate entry of at least West Nile Virus (6). TLR3 is ocated in the membrane and expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors.(7)Synonyms: Toll-like receptor 3
    Gene ID
    9606
    UniProt
    O15455
    Pathways
    TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
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