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Adiponectin (ADIPOQ ) (N-Term) antibody

Details for Product No. ABIN265161, Supplier: Log in to see
Antigen
Epitope
N-Term
55
46
25
15
13
11
11
10
7
6
6
6
5
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
503
179
135
30
16
4
4
4
3
1
Host
Rabbit
369
252
16
9
4
3
Clonality
Polyclonal
Conjugate
Un-conjugated
66
30
25
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
459
365
116
81
55
49
47
42
35
14
9
8
6
5
2
2
2
2
2
1
1
1
1
1
1
1
Options
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Immunogen A 15 amino acid peptide from near the amino terminus of human adiponectin
Isotype IgG
Specificity This antibody detects Adiponectin.
Purification Affinity chromatography
Alternative Name Adiponectin
Background Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines (reviewed in 1). One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-?-related proteins (CTRPs) 1-7 (2). Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes (3). These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene (4). It is present in high levels in normal human plasma, but is reduced in obese subjects and often in those with increased insulin resistance and type 2 diabetes, suggesting that adiponectin may be a useful pharmacological target in various metabolic diseases (5). Adiponectin a secreted protein synthesized exclusively by adipocytes (6).Synonyms: 30 kDa adipocyte complement-related protein, ACDC, ACRP30, ADIPOQ, APM1, Adipocyte, Adipocyte complement-related 30 kDa protein, Adipose most abundant gene transcript 1 protein, C1q and collagen domain-containing protein, GBP28, Gelatin-binding protein
Gene ID 9370
NCBI Accession NP_001171271
UniProt Q15848
Research Area Cancer, Atherosclerosis, Metabolism, Hormones
Application Notes Western Blot: 1 μg/mL. Positive Control: Rat brain cell lysate. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline with 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Supplier Images
 image for anti-Adiponectin  (ADIPOQ ) (N-Term) antibody (ABIN265161) anti-Adiponectin (ADIPOQ ) (N-Term) antibody
Background publications Fantuzzi: "Adipose tissue, adipokines, and inflammation." in: The Journal of allergy and clinical immunology, Vol. 115, Issue 5, pp. 911-9; quiz 920, 2005 (PubMed).

Lihn, Pedersen, Richelsen: "Adiponectin: action, regulation and association to insulin sensitivity." in: Obesity reviews : an official journal of the International Association for the Study of Obesity, Vol. 6, Issue 1, pp. 13-21, 2005 (PubMed).

Wong, Wang, Hug, Tsao, Lodish: "A family of Acrp30/adiponectin structural and functional paralogs." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10302-7, 2004 (PubMed).

Tsao, Lodish, Fruebis: "ACRP30, a new hormone controlling fat and glucose metabolism." in: European journal of pharmacology, Vol. 440, Issue 2-3, pp. 213-21, 2002 (PubMed).

Shapiro, Scherer: "The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor." in: Current biology : CB, Vol. 8, Issue 6, pp. 335-8, 1998 (PubMed).