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JAK2 antibody (Janus Kinase 2) (C-Term)

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Synonyms JAK2bCA, jak2, JTK10, THCYT3, AI504024, C81284, Fd17, JAK-2
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(49), (25), (20), (19), (13), (12), (11), (11), (9), (8), (7), (6), (6), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine), Rat (Rattus)
(236), (150), (141), (8), (7), (6), (6), (2), (1), (1), (1)
(234), (12), (5)
This JAK2 antibody is un-conjugated
(9), (6), (6), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Western Blotting (WB)
(162), (107), (91), (27), (24), (23), (15), (9), (5), (5), (3), (3)
Pubmed 12 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Chemically synthesized peptide derived from the C-terminal region of human JAK2
Isotype IgG
Specificity This antibody detects JAK2. Jak2 is expressed in blood, bone marrow and lymph node.
Purification Affinity chromatography
Alternative Name Tyrosine-Protein Kinase JAK2 (JAK2 Antibody Abstract)
Background Janus Activating Kinase 2 (JAK2) is a 130 kDa tyrosine kinase involved in cytoplasmic signal transduction. Ligand binding to a variety of cell surface receptors (e.g., cytokine, growth factor, GPCRs) leads to an association of those receptors with JAK proteins, which are then activated via phosphorylation on tyrosines 1007 and 1008 in the kinase activation loop. Activated JAK proteins phosphorylate and activate STAT (signal transducers and activators of transcription) proteins, which then dimerize and translocate to the nucleus. Once in the nucleus, STAT proteins bind to DNA and modify the transcription of various genes, which can lead to various responses such as cell proliferation, cell survival and differentiation. The JAK2 antibody is useful as a positive control and for measuring total JAK2 protein levels to compare signals obtained with the JAK2 PSSA.Synonyms: JAK-2, Janus kinase 2
Gene ID 3717
NCBI Accession NP_004963
UniProt O60674
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway
Application Notes Western blot: 0.5-1.0 μg/mL. Positive control: Human epidermoid carcinoma (A431) cells, 3T3-L1 adipocytes.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.3, with 1.0 mg/mL BSA and 0.05 % sodium azide and 50 % glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Supplier Images
 image for anti-JAK2 antibody (Janus Kinase 2) (C-Term) (ABIN265197) anti-Janus Kinase 2 (JAK2) (C-Term) antibody
Background publications Frank, Mifune, Inagami et al.: "Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta." in: Molecular and cellular biology, Vol. 23, Issue 5, pp. 1581-9, 2003 (PubMed).

Shaw, Bencherif, Marrero: "Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 44920-4, 2002 (PubMed).

Zeng, Yellaturu, Neeli et al.: "5(S)-hydroxyeicosatetraenoic acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and phosphatidylinositol 3-kinase/Akt signaling, leading to induction of expression of basic fibroblast growth factor 2." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 41213-9, 2002 (PubMed).

Sutherland, Chalupny, Schooley et al.: "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 2, pp. 671-9, 2002 (PubMed).

Kirito, Watanabe, Sawada et al.: "Thrombopoietin regulates Bcl-xL gene expression through Stat5 and phosphatidylinositol 3-kinase activation pathways." in: The Journal of biological chemistry, Vol. 277, Issue 10, pp. 8329-37, 2002 (PubMed).

Myers, Andersen, Cheng et al.: "TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B." in: The Journal of biological chemistry, Vol. 276, Issue 51, pp. 47771-4, 2001 (PubMed).

Madamanchi, Li, Patterson et al.: "Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 18915-24, 2001 (PubMed).

Madamanchi, Li, Patterson et al.: "Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 21, Issue 3, pp. 321-6, 2001 (PubMed).

Eguchi, Dempsey, Frank et al.: "Activation of MAPKs by angiotensin II in vascular smooth muscle cells. Metalloprotease-dependent EGF receptor activation is required for activation of ERK and p38 MAPK but not for JNK." in: The Journal of biological chemistry, Vol. 276, Issue 11, pp. 7957-62, 2001 (PubMed).

Amiri, Venema, Wang et al.: "Hyperglycemia enhances angiotensin II-induced janus-activated kinase/STAT signaling in vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 274, Issue 45, pp. 32382-6, 1999 (PubMed).

Ihle: "STATs: signal transducers and activators of transcription." in: Cell, Vol. 84, Issue 3, pp. 331-4, 1996 (PubMed).

Manning, DiSalvo, Stull: "Protein phosphorylation: quantitative analysis in vivo and in intact cell systems." in: Molecular and cellular endocrinology, Vol. 19, Issue 1, pp. 1-19, 1980 (PubMed).

Catalog No. ABIN265197
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