LASS1 antibody

Catalog No. ABIN265220

Product Details anti-LASS1 Antibody

Target: LASS1 (CERS1) (Ceramide Synthase 1 (CERS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LASS1 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects Lass1. Detects also GDF1.

Cross-Reactivity (Details): Cross reacts with GDF1

Purification: Affinity chromatography

Immunogen: Synthetic peptide derived from the human Lass1 protein

Application Details

Application Notes: Western blot (1: 400 starting dilution). Positive control: Hypothalamus.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.

Target Details for LASS1

Target: LASS1 (CERS1) (Ceramide Synthase 1 (CERS1))

Alternative Name: LASS1 (CERS1 Products)

Synonyms: LAG1 antibody, LASS1 antibody, UOG1 antibody, Lass1 antibody, Uog-1 antibody, to antibody, LAG1 HOMOLOG 1 antibody, LONGEVITY ASSURANCE GENE 1 antibody, ceramide synthase 1 antibody, TRAM, LAG1 and CLN8 (TLC) lipid-sensing domain containing protein antibody, CERS1 antibody, Cers1 antibody, LAG1 antibody

Background: LAG1 is a longevity gene, the first such gene to be identified. Originally cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, LAC1, has been found in the yeast genome. The human homolog of LAG1 has functions in human aging. LAG1 may be involved in neurodegenerative diseases and human aging. Lass1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner. Located in the endoplasmic reticulum membrane, LAss1 is a multi-pass membrane protein.Synonyms: LAG1, LAG1 longevity assurance homolog 1, LASS1, Longevity assurance gene 1 protein homolog 1, UOG1

Gene ID: 10715

NCBI Accession: NP_067090

UniProt: P27544