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FOXP3 antibody (Forkhead Box P3)

Details for Product anti-FOXP3 Antibody No. ABIN265254, Supplier: Log in to see
Antigen
  • foxp3
  • FOXP3
  • AIID
  • DIETER
  • IPEX
  • PIDX
  • XPID
  • JM2
  • scurfin
  • sf
  • RGD1562112
Reactivity
Human
324
185
57
22
22
21
16
12
9
8
2
2
1
1
Host
Rabbit
204
131
66
32
Clonality
Polyclonal
Conjugate
This FOXP3 antibody is un-conjugated
35
28
21
17
15
12
11
10
6
4
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
Application
Western Blotting (WB)
239
167
141
86
38
31
29
29
18
17
15
6
5
4
2
2
2
1
1
Supplier
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Immunogen Synthetic peptide derived from human FOXP3 protein
Specificity This antibody detects FOXP3.
Purification Purified
Alternative Name FOXP3 (FOXP3 Antibody Abstract)
Background Probable transcription factor. Plays a critical role in the control of immune response. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin
Gene ID 50943
NCBI Accession NP_001107849
UniProt Q9BZS1
Research Area Immunology, Adaptive Immunity, Transcription Factors
Application Notes Western blot (1-5 g).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline with 0.08 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Background publications Brunkow, Jeffery, Hjerrild et al.: "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse." in: Nature genetics, Vol. 27, Issue 1, pp. 68-73, 2001 (PubMed).

Bennett, Christie, Ramsdell et al.: "The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3." in: Nature genetics, Vol. 27, Issue 1, pp. 20-1, 2001 (PubMed).

Wildin, Ramsdell, Peake et al.: "X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy." in: Nature genetics, Vol. 27, Issue 1, pp. 18-20, 2001 (PubMed).