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FOXP3 antibody (Forkhead Box P3)

Details for Product anti-FOXP3 Antibody No. ABIN265254, Supplier: Log in to see
Antigen
  • foxp3
  • FOXP3
  • AIID
  • DIETER
  • IPEX
  • PIDX
  • XPID
  • JM2
  • scurfin
  • sf
  • RGD1562112
  • forkhead box P3
  • forkhead box P3a
  • transcription factor foxp3
  • FOXP3
  • foxp3a
  • LOC100348270
  • foxp3
  • Foxp3
Alternatives
anti-Human FOXP3 antibody for Immunohistochemistry
Reactivity
Human
423
283
61
44
19
13
12
7
6
4
3
1
1
1
1
1
Host
Rabbit
254
188
37
31
Clonality
Polyclonal
Conjugate
This FOXP3 antibody is un-conjugated
37
32
21
19
19
18
18
10
9
9
9
7
6
6
5
5
3
3
3
3
2
Application
Western Blotting (WB)
297
206
180
103
89
77
76
59
30
17
5
4
4
4
2
2
2
1
1
Options
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Immunogen Synthetic peptide derived from human FOXP3 protein
Specificity This antibody detects FOXP3.
Purification Purified
Alternative Name FOXP3 (FOXP3 Antibody Abstract)
Background Probable transcription factor. Plays a critical role in the control of immune response. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin
Gene ID 50943
NCBI Accession NP_001107849
UniProt Q9BZS1
Research Area Immunology, Adaptive Immunity, Transcription Factors
Pathways Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Application Notes Western blot (1-5 g).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer Phosphate buffered saline with 0.08 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the product (in aliquots) at -20 °C. Can be shipped at 2 - 8 °C.
Background publications Bennett, Christie, Ramsdell, Brunkow, Ferguson, Whitesell, Kelly, Saulsbury, Chance, Ochs: "The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3." in: Nature genetics, Vol. 27, Issue 1, pp. 20-1, 2001 (PubMed).

Wildin, Ramsdell, Peake, Faravelli, Casanova, Buist, Levy-Lahad, Mazzella, Goulet, Perroni, Bricarelli, Byrne, McEuen, Proll, Appleby, Brunkow: "X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy." in: Nature genetics, Vol. 27, Issue 1, pp. 18-20, 2001 (PubMed).

Brunkow, Jeffery, Hjerrild, Paeper, Clark, Yasayko, Wilkinson, Galas, Ziegler, Ramsdell: "Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse." in: Nature genetics, Vol. 27, Issue 1, pp. 68-73, 2001 (PubMed).