Exportin 2 antibody
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- Target See all Exportin 2 (CSE1L) Antibodies
- Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Exportin 2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- This antibody detects endogenous levels of XPO2 / Exportin-2 protein (region surrounding Glu2).
- Cross-Reactivity (Details)
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Purification
- The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen
- Purity
- > 95 % pure by SDS-PAGE
- Top Product
- Discover our top product CSE1L Primary Antibody
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- Application Notes
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ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. IP: 1: 50approx. 1: 200. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))
- Alternative Name
- XPO2 / Exportin-2 (CSE1L Products)
- Synonyms
- BcDNA:LD14270 antibody, CAS antibody, CG13281 antibody, Dcas antibody, Dmel\\CG13281 antibody, cas antibody, dcas antibody, l(2)k03902 antibody, CSE1L antibody, XPO2 antibody, Exportin-2 antibody, DKFZp459E1929 antibody, 2610100P18Rik antibody, AA407533 antibody, Capts antibody, Cas antibody, Xpo2 antibody, xpo2 antibody, CSE1 antibody, CAS/CSE1 segregation protein antibody, chromosome segregation 1 like antibody, exportin-2 antibody, chromosome segregation 1-like (S. cerevisiae) antibody, CSE1 chromosome segregation 1-like (yeast) antibody, CSE1 chromosome segregation 1-like L homeolog antibody, Cas antibody, CSE1L antibody, LOC100542094 antibody, cse1l antibody, Cse1l antibody, cse1l.L antibody
- Background
- Normal tissues are characterized by a balance between cellular stasis, cell proliferation, cell differentiation and cell death. Aberrant regulation of any of these cell processes can result in cancer. Cell death during embryogenesis, tissue atrophy and normal tissue turnover is called apoptosis. This is characterized by cytoplasmic and nuclear condensation, nuclear disorganization and fragmentation of genomic DNA into 180-200 base pair oligomers. Several human cDNA fragments have been shown to render MCF-7 cells resistant to cell death induced by Pseudomonas exotoxin, Pseudomonas exotoxin-derived immunotoxins, diptheria toxin and tumor necrosis factor (TNF). One such fragment has proven to be the human homolog to the yeast chromosome segregation homolog, CSE1. Cloning of the full-length human cDNA has revealed a putative protein designated CAS, for cellular apoptosis susceptibility, that is 971 amino acids in length with 59 % overall sequence homology as compared to yeast CSE1. CAS is highly expressed in testis and fetal liver. CAS expression in human fibroblasts increases as cells are induced to proliferate and decreases in growth arrested cells.Synonyms: CAS, CSE1L, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Exp2, Importin-alpha re-exporter
- Molecular Weight
- approx. 110 kDa
- Gene ID
- 1434
- NCBI Accession
- NP_001307
- UniProt
- P55060
- Pathways
- Protein targeting to Nucleus
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