Cyclin G1 antibody

Catalog No. ABIN265382

Product Details anti-Cyclin G1 Antibody

Target: Cyclin G1 (CCNG1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin G1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of Cyclin G protein. (region surrounding Ile194)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH ~7.2, 0.05 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Cyclin G1

Target: Cyclin G1 (CCNG1)

Alternative Name: Cyclin G1 (CCNG1 Products)

Synonyms: CCNG antibody, AI314029 antibody, CYCG antibody, Ccng antibody, CG 11525 antibody, CG11525 antibody, Dmel\\CG11525 antibody, anon-EST:Liang-1.25 antibody, anon-EST:Liang-2.24 antibody, clone 1.25 antibody, clone 2.24 antibody, dCycG antibody, i205 antibody, i261 antibody, cb138 antibody, fd08g04 antibody, sb:cb138 antibody, wu:fb07e04 antibody, wu:fd08g04 antibody, zgc:56595 antibody, ccng1 antibody, cyclin G1 antibody, Cyclin G antibody, cyclin G1 S homeolog antibody, CCNG1 antibody, Ccng1 antibody, CycG antibody, ccng1 antibody, ccng1.S antibody

Background: Cyclins are the regulatory subunits of Cdc2 p34 and related cyclin-dependent kinases (Cdks) which play critical roles in the control of cell cycle progression. The catalytic subunit for cyclin A and B is Cdc2 p34 kinase. The Cdc2- cyclin B complex controls the G2 to M transition whereas Cdc2-cyclin A regulates S phase progression. The G1 to S transition, however, appears to be controlled by the G1 cyclins. Cyclin D1 accumulates during G1 and associates with Cdk2, Cdk4 and Cdk5. Cyclin E and Cdk2 interact during the G1 to S transition. Cyclin G contains a typical N terminal cyclin box and a carboxy terminal domain sequence homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor. Cyclin G expression is induced within 3 hours after growth stimulation and remains elevated with no apparent cell cycle dependency. Cyclin G2 shares 53 % amino acid sequence identity with cyclin G1. Peak expression of cyclin G2 is seen in late S phase, as opposed to cyclin G1 expression, which is constitutive.Synonyms: CCNG, CCNG1, CYCG1, Cyclin-G, Cyclin-G1

Molecular Weight: approx. 29 kDa

Gene ID: 900

NCBI Accession: NP_004051

UniProt: P51959

Pathways: p53 Signaling