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IL-6 Receptor antibody (APC)

IL6R Reactivity: Human WB, ELISA Host: Mouse Monoclonal UV4 APC
Catalog No. ABIN2656902
  • Target See all IL-6 Receptor (IL6R) Antibodies
    IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
    Reactivity
    • 49
    • 19
    • 16
    Human
    Host
    • 47
    • 22
    • 5
    • 1
    • 1
    Mouse
    Clonality
    • 50
    • 25
    • 1
    Monoclonal
    Conjugate
    • 49
    • 13
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL-6 Receptor antibody is conjugated to APC
    Application
    • 51
    • 23
    • 22
    • 21
    • 12
    • 9
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Purification
    The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
    Clone
    UV4
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product IL6R Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from prolonged exposure to light. Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C
  • Target
    IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
    Alternative Name
    CD126 (IL6R Products)
    Synonyms
    IL6R antibody, il-6ra antibody, CD126 antibody, IL-6R-1 antibody, IL-6RA antibody, IL6Q antibody, IL6RA antibody, IL6RQ antibody, gp80 antibody, IL6R1 antibody, Il6ra antibody, IL-6Ralpha antibody, IL-6R antibody, Il6r antibody, interleukin 6 receptor antibody, interleukin 6 receptor, alpha antibody, IL6R antibody, il6r antibody, Il6r antibody, Il6ra antibody
    Background
    CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on plasma cells, T cells, activated B cells, monocytes, granulocytes, hepatocytes, epithelial cells, and fibroblasts. Functional IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. A soluble form of CD126 has been found in human serum.
    Pathways
    JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints
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