Klra4 antibody (Alexa Fluor 647)
Klra4
Reactivity: Mouse
FACS
Host: Rat
Monoclonal
4E5
Alexa Fluor 647
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- Target See all Klra4 products
- Klra4 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4))
- Reactivity
- Mouse
- Host
- Rat
- Clonality
- Monoclonal
- Conjugate
- This Klra4 antibody is conjugated to Alexa Fluor 647
- Application
- Flow Cytometry (FACS)
- Purification
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
- Clone
- 4E5
- Isotype
- IgG2a kappa
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect from prolonged exposure to light. Do not freeze.
- Storage
- 4 °C
- Storage Comment
- The antibody solution should be stored undiluted between 2°C and 8°C
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- Target
- Klra4 (Killer Cell Lectin-Like Receptor, Subfamily A, Member 4 (Klra4))
- Alternative Name
- Ly49D (Klra4 Products)
- Synonyms
- Chok antibody, Klra32 antibody, Ly-49d antibody, Ly49d antibody, ly49r<129> antibody, killer cell lectin-like receptor, subfamily A, member 4 antibody, Klra4 antibody
- Background
- Ly49D is a type II transmembrane protein belonging to the Ly49 family of NK-cell receptors in the C-type lectin superfamily. Ly49D is expressed on subsets of natural killer (NK) cells in C57BL/6, C3H/He and SJL mouse strains, but not Balb/c, DBA/2, AKR and CBA/J. The receptors form homodimers that bind to MHC class I alloantigens. Unlike inhibitory Ly49 family members, Ly49D lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) but contains a cytoplasmic immunoreceptor tyrosine-based activation motif. The activating receptor Ly49D delivers stimulatory signals for target cell lysis upon interacting with H2-Dd, Dr and Dsp2, but not with H2b or H2k class I antigens. Cross-linking of Ly49D activates intracellular kinase activity and calcium mobilization in NK cells. In 129/J mice, 4E5 antibody cross-reacts with Ly49O, LY49R and Ly49V.
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