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BTLA antibody (Alexa Fluor 647)

BTLA Reactivity: Mouse FACS Host: Mouse Monoclonal 8F4 Alexa Fluor 647
Catalog No. ABIN2657719
  • Target See all BTLA Antibodies
    BTLA (B and T Lymphocyte Associated (BTLA))
    Reactivity
    • 59
    • 31
    • 4
    • 2
    • 1
    • 1
    Mouse
    Host
    • 33
    • 25
    • 11
    • 3
    • 1
    • 1
    Mouse
    Clonality
    • 40
    • 32
    • 2
    Monoclonal
    Conjugate
    • 45
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BTLA antibody is conjugated to Alexa Fluor 647
    Application
    • 47
    • 44
    • 27
    • 13
    • 13
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    Flow Cytometry (FACS)
    Purification
    The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.
    Clone
    8F4
    Isotype
    IgG1 kappa
    Top Product
    Discover our top product BTLA Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Protect from prolonged exposure to light. Do not freeze.
    Storage
    4 °C
    Storage Comment
    The antibody solution should be stored undiluted between 2°C and 8°C
  • Target
    BTLA (B and T Lymphocyte Associated (BTLA))
    Alternative Name
    CD272 (BTLA Products)
    Synonyms
    BTLA antibody, BTLA1 antibody, CD272 antibody, A630002H24 antibody, B and T lymphocyte associated antibody, BTLA antibody, Btla antibody
    Background
    B and T lymphocyte attenuator (BTLA) is an Ig superfamily coinhibitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand Herpes Virus Entry Mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, reduced effectiveness of T regulatory cells. BTLA takes an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significant up-regulated expression of BTLA compared with effector and naive T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4. But further studies are needed to confirm. The existence of three distinct BTLA alleles was reported. The BTLA antibody reacts with mouse BTLA from both BALb/c and C57BL/6 strains.
    Pathways
    Cancer Immune Checkpoints
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