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NOTCH3 antibody (Alexa Fluor 647)
NOTCH3
Reactivity: Mouse
FACS
Host: Hamster
Monoclonal
HMN3-133
Alexa Fluor 647
Product Details anti-NOTCH3 Antibody (Alexa Fluor 647)
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Target
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NOTCH3
(Notch 3 (NOTCH3))
Reactivity
All reactivities for NOTCH3 antibodies
Mouse
Host
All hosts for NOTCH3 antibodies
Hamster
Clonality
All clonalities for NOTCH3 antibodies
Monoclonal
Conjugate
All conjugates for NOTCH3 antibodies
This NOTCH3 antibody is conjugated to Alexa Fluor 647
Application
All applications for NOTCH3 antibodies
Flow Cytometry (FACS)
Purification
The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.
Clone
HMN3-133
Isotype
IgG
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Discover our top product NOTCH3 Primary Antibody
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Protect from prolonged exposure to light. Do not freeze.
Storage
4 °C
Storage Comment
The antibody solution should be stored undiluted between 2°C and 8°C
Target Details for NOTCH3
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Target
NOTCH3
(Notch 3 (NOTCH3))
Alternative Name
Notch 3 (NOTCH3 Products )
Synonyms
CADASIL antibody, CASIL antibody, IMF2 antibody, AW229011 antibody, N3 antibody, hpbk antibody, fa14b08 antibody, notch5 antibody, wu:fa14b08 antibody, notch 3 antibody, NOTCH3 antibody, Notch3 antibody, notch3 antibody
Background
The Notch receptors are highly conserved from invertebrates to mammals.While Notch1 and Notch 2 exhibit the highest structural similarity among the four mammalian Notch receptors. Notch 3 has a number of structural and functional differences.The binding of Notch 3 to its ligands results in the proteolysis of Notch and movement of intracellular portions of Notch into the nucleus.This translocation triggers a series of signaling process.Notch 3 is primarily expressed in adult arterial smooth muscle cells.Notch 3 gene mutation can cause CADASIL, an inherited early stroke syndrome.
Pathways
Notch Signaling
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